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Tbio
Q9BZG1
Ras-related protein Rab-34

Protein Summary
Description
Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301043
  • ENSP00000301043
  • ENSG00000109113
  • ENST00000395245
  • ENSP00000378666
  • ENST00000415040
  • ENSP00000410279
  • ENST00000436730
  • ENSP00000404180
  • ENST00000450529
  • ENSP00000391048

Symbol
  • RAB39
  • RAH
  • RAH
  • NARR
  • RAB39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cellular component
0.89
kinase perturbation
0.84
virus perturbation
0.79
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999999695
p_ni:  3.02e-7
p_wrong:  3e-9
Score:  0.565
Data Source:  BioPlex,STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
p_int:  0.999998577
p_ni:  0.000001423
Score:  0.243
Data Source:  BioPlex,STRINGDB
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.999972365
p_ni:  0.000025588
p_wrong:  0.000002047
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.989583034
p_ni:  0.001541105
p_wrong:  0.008875861
Data Source:  BioPlex
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.889281075
p_ni:  0.110718925
Score:  0.27
Data Source:  BioPlex,STRINGDB
SNX11
Tdark
Novelty:  0.21586113
p_int:  0.809090616
p_ni:  0.113615016
p_wrong:  0.077294369
Score:  0.317
Data Source:  BioPlex,STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.959
Data Source:  STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.94
Data Source:  STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.938
Data Source:  STRINGDB
RAB2A
Tchem
Family:  Enzyme
Novelty:  0.00629151
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
2
83.2
reticulocyte count
2
2
4
83
reticulocyte measurement
1
1
2
58.4
mean platelet volume
1
1
2
44.2
total cholesterol measurement
1
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
83.2
reticulocyte count
4
83
reticulocyte measurement
2
58.4
mean platelet volume
2
44.2
total cholesterol measurement
2
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ras-related protein Rab-34
709951
Mouse
MGI:104606
19376
Rat
RGD:1305058
360571
Dog
RAB34, member RAS oncogene family
VGNC:45277
612952
Horse
RAB34, member RAS oncogene family
VGNC:22110
100072072
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ras-related protein Rab-34
Mouse
Rat
Dog
RAB34, member RAS oncogene family
Horse
RAB34, member RAS oncogene family
Publication Statistics
PubMed Score 46.14
PubMed score by year
PubTator Score 28.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title