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Tbio
UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

Protein Summary
Description
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322954
  • ENSP00000314556
  • ENSG00000137831
  • ENST00000379983
  • ENSP00000369319

Symbol
  • KIAA1561
  • NUCLING
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
biological process
0.8
histone modification site profile
0.8
virus perturbation
0.76
transcription factor binding site profile
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uveal autoantigen with coiled-coil domains and ankyrin repeats
VGNC:3521
453547
Macaque
uveal autoantigen with coiled-coil domains and ankyrin repeats
696026
Mouse
MGI:1919815
72565
Rat
RGD:1560011
315732
Dog
uveal autoantigen with coiled-coil domains and ankyrin repeats
VGNC:48034
403704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uveal autoantigen with coiled-coil domains and ankyrin repeats
Macaque
uveal autoantigen with coiled-coil domains and ankyrin repeats
Mouse
Rat
Dog
uveal autoantigen with coiled-coil domains and ankyrin repeats
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZF9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Cytochrome c-mediated apoptotic response
Reactome
Formation of apoptosome
Reactome
Intrinsic Pathway for Apoptosis
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Intrinsic Pathway for Apoptosis
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (63)
1 – 10 of 63
RGS3
Tbio
Novelty: 0.01749541
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.151
Data Source: BioPlex,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.999999901
p_ni: 9.9e-8
Data Source: BioPlex
JPH4
Tbio
Novelty: 0.07699598
p_int: 0.999999478
p_ni: 5.12e-7
p_wrong: 1e-8
Data Source: BioPlex
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.999998859
p_ni: 0.000001141
Data Source: BioPlex
CORO6
Tdark
Novelty: 0.37416507
p_int: 0.999998779
p_ni: 0.00000122
p_wrong: 1e-9
Score: 0.22
Data Source: BioPlex,STRINGDB
PICK1
Tbio
Novelty: 0.0058265
p_int: 0.999995054
p_ni: 0.000004929
p_wrong: 1.6e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
IFT22
Tbio
Family: Enzyme
Novelty: 0.18342877
p_int: 0.999992111
p_ni: 0.000007889
Data Source: BioPlex
RNASEH1
Tchem
Family: Enzyme
Novelty: 0.01838314
p_int: 0.999991325
p_ni: 0.000008675
Data Source: BioPlex
BTN3A1
Tbio
Novelty: 0.02572232
p_int: 0.999952734
p_ni: 0.000047265
Data Source: BioPlex
PNMA5
Tdark
Novelty: 0.38868015
p_int: 0.999943983
p_ni: 0.000055976
p_wrong: 4e-8
Score: 0.228
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21.02

PubMed score by year
PubTator Score  8.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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