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Tbio
OSBPL6
Oxysterol-binding protein-related protein 6

Protein Summary
Description
Weakly binds 25-hydroxycholesterol. This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000190611
  • ENSP00000190611
  • ENSG00000079156
  • ENST00000315022
  • ENSP00000318723
  • ENST00000357080
  • ENSP00000349591
  • ENST00000359685
  • ENSP00000352713
  • ENST00000392505
  • ENSP00000376293
  • ENST00000409045
  • ENSP00000387248
  • ENST00000409631
  • ENSP00000386885

Symbol
  • ORP6
  • ORP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
trait
0.86
histone modification site profile
0.84
kinase perturbation
0.81
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999979
p_ni:  2.1e-8
Score:  0.776
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.999999921
p_ni:  7.9e-8
Data Source:  BioPlex
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999994879
p_ni:  0.000005121
Score:  0.747
Data Source:  BioPlex,STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.999973043
p_ni:  0.000026957
Data Source:  BioPlex
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.99996382
p_ni:  0.00003618
Score:  0.154
Data Source:  BioPlex,STRINGDB
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.999376642
p_ni:  0.000623358
Score:  0.165
Data Source:  BioPlex,STRINGDB
ILVBL
Tbio
Family:  Enzyme
Novelty:  0.00297467
p_int:  0.998548627
p_ni:  0.001451373
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.997759669
p_ni:  0.002240331
Data Source:  BioPlex
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.996854522
p_ni:  0.003145478
Data Source:  BioPlex
PHTF2
Tdark
Novelty:  0.52825058
p_int:  0.995913219
p_ni:  0.004086781
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
8.1
65.6
vital capacity
1
1
1
47.7
refractive error measurement
1
1
1
38.2
electrocardiography
1
1
3
30.2
forced expiratory volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
8.1
65.6
vital capacity
1
47.7
refractive error measurement
1
38.2
electrocardiography
3
30.2
forced expiratory volume
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 6
VGNC:2742
459775
Macaque
oxysterol binding protein like 6
708349
Mouse
MGI:2139014
99031
Rat
RGD:1308887
311129
Dog
oxysterol binding protein like 6
VGNC:44156
478816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 6
Macaque
oxysterol binding protein like 6
Mouse
Rat
Dog
oxysterol binding protein like 6
Publication Statistics
PubMed Score 3.93
PubMed score by year
PubTator Score 3.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title