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Tbio
OSBPL6
Oxysterol-binding protein-related protein 6

Protein Summary
Description
Weakly binds 25-hydroxycholesterol. This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000190611
  • ENSP00000190611
  • ENSG00000079156
  • ENST00000315022
  • ENSP00000318723
  • ENST00000357080
  • ENSP00000349591
  • ENST00000359685
  • ENSP00000352713
  • ENST00000392505
  • ENSP00000376293
  • ENST00000409045
  • ENSP00000387248
  • ENST00000409631
  • ENSP00000386885

Symbol
  • ORP6
  • ORP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
trait
0.86
histone modification site profile
0.84
kinase perturbation
0.81
transcription factor binding site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
34.9
1
1
0
5.5
26.3
age at onset
1
1
0
5.5
26.3
forced expiratory volume
1
1
1
20.1
electrocardiography
1
1
3
18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
34.9
0
5.5
26.3
age at onset
0
5.5
26.3
forced expiratory volume
1
20.1
electrocardiography
3
18
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 6
VGNC:2742
459775
Macaque
oxysterol binding protein like 6
708349
Mouse
MGI:2139014
99031
Rat
RGD:1308887
311129
Dog
oxysterol binding protein like 6
VGNC:44156
478816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 6
Macaque
oxysterol binding protein like 6
Mouse
Rat
Dog
oxysterol binding protein like 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZF3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (49)
1 – 10 of 49
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999999979
p_ni: 2.1e-8
Score: 0.776
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00353077
p_int: 0.999999921
p_ni: 7.9e-8
Data Source: BioPlex
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999994879
p_ni: 0.000005121
Score: 0.747
Data Source: BioPlex,STRINGDB
KLRD1
Tbio
Novelty: 0.00218019
p_int: 0.999973043
p_ni: 0.000026957
Data Source: BioPlex
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.99996382
p_ni: 0.00003618
Score: 0.154
Data Source: BioPlex,STRINGDB
ZFPL1
Tbio
Novelty: 0.1829181
p_int: 0.999376642
p_ni: 0.000623358
Score: 0.165
Data Source: BioPlex,STRINGDB
ILVBL
Tbio
Family: Enzyme
Novelty: 0.00297467
p_int: 0.998548627
p_ni: 0.001451373
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.997759669
p_ni: 0.002240331
Data Source: BioPlex
ARRDC1
Tbio
Novelty: 0.10481621
p_int: 0.996854522
p_ni: 0.003145478
Data Source: BioPlex
PHTF2
Tdark
Novelty: 0.52825058
p_int: 0.995913219
p_ni: 0.004086781
Data Source: BioPlex
Publication Statistics
PubMed Score  3.93

PubMed score by year
PubTator Score  3.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer