Tbio OSBPL8 Oxysterol-binding protein-related protein 8

Protein Summary

Description

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q9BZF1
• A8K1T2
• E9PE66
• E9PE68
• Q52LQ3
• Q68D75
• Q8WXP8
• Q9P277
• ORP-8

Gene Name

• OSBPL8

Ensembl ID

• ENST00000261183
• ENSP00000261183
• ENSG00000091039
• ENST00000393249
• ENSP00000376939
• ENST00000393250
• ENSP00000376940
• ENST00000611266
• ENSP00000478240

Symbol

• KIAA1451
• ORP8
• OSBP10
• ORP8
• MST120
• OSBP10
• MSTP120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
microRNA	0.9
transcription factor binding site profile	0.84
disease perturbation	0.79
histone modification site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0