Tchem GTPBP4 Nucleolar GTP-binding protein 1

Protein Summary

Description

Involved in the biogenesis of the 60S ribosomal subunit. GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BZE4
• B3KMC5
• B4DY13
• B7Z7A3
• O95446
• Q5T3R8
• Q9NVJ8

Gene Name

• GTPBP4

Ensembl ID

• ENST00000360803
• ENSP00000354040
• ENSG00000107937

Symbol

• CRFG
• NOG1
• NGB
• CRFG
• NOG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
molecular function	0.95
transcription factor binding site profile	0.9
histone modification site profile	0.89
hub protein	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1382.11   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1382.11   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0