You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
PRRG4
Transmembrane gamma-carboxyglutamic acid protein 4

Protein Summary
Description
May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (PubMed:28859078).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257836
  • ENSP00000257836
  • ENSG00000135378

Symbol
  • PRGP4
  • TMG4
  • TMG4
  • PRGP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor perturbation
0.8
PubMedID
0.68
kinase perturbation
0.66
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
71.6
platelet crit
1
1
1
69.2
sex hormone-binding globulin measurement
4
1
4
66.8
platelet count
1
1
1
56.2
smoking status measurement
2
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
71.6
platelet crit
1
69.2
sex hormone-binding globulin measurement
4
66.8
platelet count
1
56.2
smoking status measurement
2
35
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2442211
228413
Rat
RGD:1560542
499847
Dog
proline rich and Gla domain 4
VGNC:45058
609187
Horse
proline rich and Gla domain 4
VGNC:21911
100072747
Cow
proline rich and Gla domain 4
VGNC:33409
616767
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proline rich and Gla domain 4
Horse
proline rich and Gla domain 4
Cow
proline rich and Gla domain 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
TGF-beta Signaling Pathway
Name
Explore in Pharos
Explore in Source
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
TGF-beta Signaling Pathway
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (26)
1 – 10 of 26
YAP1
Tchem
Novelty:  0.00124225
p_int:  0.999881558
p_ni:  0.000118441
p_wrong:  1e-9
Score:  0.559
Data Source:  BioPlex,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.88108207
p_ni:  0.118909217
p_wrong:  0.000008713
Score:  0.261
Data Source:  BioPlex,STRINGDB
QSER1
Tdark
Novelty:  0.62017582
Score:  0.836
Data Source:  STRINGDB
CCDC73
Tdark
Novelty:  0.80048057
Score:  0.669
Data Source:  STRINGDB
TCP11L1
Tdark
Novelty:  1.5011461
Score:  0.651
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.545
Data Source:  STRINGDB
CLEC4D
Tbio
Novelty:  0.04119682
Score:  0.541
Data Source:  STRINGDB
DEPDC7
Tdark
Novelty:  0.28944316
Score:  0.533
Data Source:  STRINGDB
EHF
Tbio
Family:  TF
Novelty:  0.00990018
Score:  0.512
Data Source:  STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
Score:  0.509
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.78

PubMed score by year
PubTator Score  4.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: