Tbio NUF2 Kinetochore protein Nuf2

Protein Summary

Description

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BZD4
• Q8WU69
• Q96HJ4
• Q96Q78
• hNuf2

Gene Name

• NUF2

Ensembl ID

• ENST00000271452
• ENSP00000271452
• ENSG00000143228
• ENST00000367900
• ENSP00000356875

Symbol

• CDCA1
• NUF2R
• CDCA1
• CT106
• NUF2R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.94
histone modification site profile	0.9
interacting protein	0.89
drug perturbation	0.71
cellular component	0.69

Protein Classes

PANTHER Classes

Protein / Structural Protein / Kinetochore Protein Nuf2

DTO Classes

Protein / Cellular Structure / Kinetochore Protein Nuf2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.66   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.66   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0