Tbio SLC29A3 Equilibrative nucleoside transporter 3

Protein Summary

Description

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9BZD2
• B2RB50
• B4E2Z9
• B7ZA37
• Q0VAM9
• Q5T465
• Q7RTT8
• Q8IVZ0
• Q9BWI2
• Q9NUS9
• hENT3

Gene Name

• SLC29A3

Ensembl ID

• ENST00000373189
• ENSP00000362285
• ENSG00000198246
• ENST00000642647
• ENSP00000495980

Symbol

• ENT3
• ENT3
• HJCD
• PHID
• HCLAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
cell type or tissue	0.71
histone modification site profile	0.69
transcription factor binding site profile	0.69
small molecule perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transporter / Equilibrative Nucleoside Transporter 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc28 And Slc29 Families Of Nucleoside Transporters / Slc29 Family / Equilibrative Nucleoside Transporter 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.3   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.3   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0