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Tbio
SLC29A3
Equilibrative nucleoside transporter 3

Protein Summary
Description
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373189
  • ENSP00000362285
  • ENSG00000198246
  • ENST00000642647
  • ENSP00000495980

Symbol
  • ENT3
  • ENT3
  • HJCD
  • PHID
  • HCLAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
cell type or tissue
0.71
histone modification site profile
0.69
transcription factor binding site profile
0.69
small molecule perturbation
0.68


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.19   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.19   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
43.4
lymphocyte count
1
1
1
43.4
1
1
0
1.1
32.4
leukocyte count
1
1
1
24.9
sleep duration
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
43.4
lymphocyte count
1
43.4
0
1.1
32.4
leukocyte count
1
24.9
sleep duration
1
3.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 29 member 3
VGNC:7865
466104
Macaque
solute carrier family 29 member 3
709682
Mouse
MGI:1918529
71279
Rat
RGD:727811
353307
Dog
solute carrier family 29 member 3
VGNC:46335
489034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 29 member 3
Macaque
solute carrier family 29 member 3
Mouse
Rat
Dog
solute carrier family 29 member 3
Pathways (9)
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) (R-HSA-5619063)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (59)
1 – 10 of 59
ACAD8
Tbio
Family: Enzyme
Novelty: 0.05735881
Score: 0.804
Data Source: STRINGDB
SLC28A1
Tbio
Family: Transporter
Novelty: 0.00745854
Score: 0.733
Data Source: STRINGDB
SLC28A3
Tchem
Family: Transporter
Novelty: 0.0117021
Score: 0.723
Data Source: STRINGDB
GCDH
Tbio
Family: Enzyme
Novelty: 0.0041805
Score: 0.719
Data Source: STRINGDB
SLC28A2
Tchem
Family: Transporter
Novelty: 0.00967399
Score: 0.719
Data Source: STRINGDB
SLC6A17
Tbio
Family: Transporter
Novelty: 0.08927323
Score: 0.714
Data Source: STRINGDB
SLC47A1
Tchem
Family: Transporter
Novelty: 0.00535064
Score: 0.703
Data Source: STRINGDB
MFSD4B
Tdark
Novelty: 0.03380333
Score: 0.697
Data Source: STRINGDB
SLC6A19
Tchem
Family: Transporter
Novelty: 0.01581031
Score: 0.693
Data Source: STRINGDB
SLC46A3
Tbio
Family: Transporter
Novelty: 0.17902241
Score: 0.689
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.19

PubMed score by year
PubTator Score  75.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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