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Tbio
CPEB1
Cytoplasmic polyadenylation element-binding protein 1

Protein Summary
Description
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611163
  • ENSP00000483857
  • ENSG00000214575
  • ENST00000615198
  • ENSP00000477715
  • ENST00000616775
  • ENSP00000482116
  • ENSG00000277445
  • ENST00000617462
  • ENSP00000477557
  • ENST00000617522
  • ENSP00000481009
  • ENST00000618449
  • ENSP00000483590
  • ENST00000619696
  • ENSP00000482965
  • ENST00000620182
  • ENSP00000484549
  • ENST00000620212
  • ENSP00000478558
  • ENST00000631674
  • ENSP00000488352
  • ENST00000632526
  • ENSP00000487757

Symbol
  • CPEB
  • CPEB
  • CPEB-1
  • h-CPEB
  • CPE-BP1
  • hCPEB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.74
transcription factor perturbation
0.74
molecular function
0.73
PubMedID
0.71
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.4   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.4   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0