Tbio CPEB1 Cytoplasmic polyadenylation element-binding protein 1

Protein Summary

Description

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q9BZB8
• B7Z6C6
• Q86W46
• Q8IV41
• Q9BZB7
• Q9H8V5
• CPE-BP1

Gene Name

• CPEB1

Ensembl ID

• ENST00000611163
• ENSP00000483857
• ENSG00000214575
• ENST00000615198
• ENSP00000477715
• ENST00000616775
• ENSP00000482116
• ENSG00000277445
• ENST00000617462
• ENSP00000477557
• ENST00000617522
• ENSP00000481009
• ENST00000618449
• ENSP00000483590
• ENST00000619696
• ENSP00000482965
• ENST00000620182
• ENSP00000484549
• ENST00000620212
• ENSP00000478558
• ENST00000631674
• ENSP00000488352
• ENST00000632526
• ENSP00000487757

Symbol

• CPEB
• CPEB
• CPEB-1
• h-CPEB
• CPE-BP1
• hCPEB-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.74
transcription factor perturbation	0.74
molecular function	0.73
PubMedID	0.71
histone modification site profile	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cytoplasmic Polyadenylation Element-binding Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cytoplasmic Polyadenylation Element-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.4   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.4   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0