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Tbio
CPEB1
Cytoplasmic polyadenylation element-binding protein 1

Protein Summary
Description
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611163
  • ENSP00000483857
  • ENSG00000214575
  • ENST00000615198
  • ENSP00000477715
  • ENST00000616775
  • ENSP00000482116
  • ENSG00000277445
  • ENST00000617462
  • ENSP00000477557
  • ENST00000617522
  • ENSP00000481009
  • ENST00000618449
  • ENSP00000483590
  • ENST00000619696
  • ENSP00000482965
  • ENST00000620182
  • ENSP00000484549
  • ENST00000620212
  • ENSP00000478558
  • ENST00000631674
  • ENSP00000488352
  • ENST00000632526
  • ENSP00000487757

Symbol
  • CPEB
  • CPEB
  • CPEB-1
  • h-CPEB
  • CPE-BP1
  • hCPEB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.74
transcription factor perturbation
0.74
molecular function
0.73
PubMedID
0.71
histone modification site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.44   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.44   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
1
1.1
81.2
4
2
1
1.1
81.2
self reported educational attainment
2
2
2
81
self reported educational attainment
2
2
2
81
cognitive function measurement
1
1
1
73.6
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
81.2
1
1.1
81.2
self reported educational attainment
2
81
self reported educational attainment
2
81
cognitive function measurement
1
73.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytoplasmic polyadenylation element binding protein 1
694357
Mouse
MGI:108442
12877
Rat
RGD:1310421
293056
Dog
cytoplasmic polyadenylation element binding protein 1
100683974
Horse
cytoplasmic polyadenylation element binding protein 1
100068411
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytoplasmic polyadenylation element binding protein 1
Mouse
Rat
Dog
cytoplasmic polyadenylation element binding protein 1
Horse
cytoplasmic polyadenylation element binding protein 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BZB8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (102)
1 – 10 of 102
SYMPK
Tbio
Novelty: 0.01773552
p_int: 0.999993197
p_ni: 0.000006794
p_wrong: 9e-9
Score: 0.947
Data Source: BioPlex,STRINGDB
METAP1D
Tbio
Family: Enzyme
Novelty: 0.17714714
p_int: 0.999990309
p_ni: 0.000009688
p_wrong: 4e-9
Score: 0.227
Data Source: BioPlex,STRINGDB
GBP5
Tbio
Novelty: 0.03705719
p_int: 0.999976175
p_ni: 0.000023815
p_wrong: 1e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
APBA3
Tbio
Novelty: 0.05059532
p_int: 0.996889919
p_ni: 0.003109568
p_wrong: 5.13e-7
Data Source: BioPlex
CSTF2T
Tbio
Novelty: 0.11811814
p_int: 0.990658461
p_ni: 0.009340764
p_wrong: 7.75e-7
Score: 0.822
Data Source: BioPlex,STRINGDB
GAN
Tbio
Novelty: 0.01069743
p_int: 0.990493192
p_ni: 0.009506808
Score: 0.177
Data Source: BioPlex,STRINGDB
NMD3
Tbio
Novelty: 0.03505289
p_int: 0.961303329
p_ni: 0.038696294
p_wrong: 3.78e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
CSTF2
Tbio
Novelty: 0.01389909
p_int: 0.791172938
p_ni: 0.208827061
Score: 0.89
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.981
Data Source: STRINGDB
NGDN
Tbio
Novelty: 0.00822392
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  245.44

PubMed score by year
PubTator Score  81.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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