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Tbio
PITPNM2
Membrane-associated phosphatidylinositol transfer protein 2

Protein Classes
Protein Summary
Description
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280562
  • ENSP00000280562
  • ENSG00000090975
  • ENST00000320201
  • ENSP00000322218
  • ENST00000542749
  • ENSP00000437611

Symbol
  • KIAA1457
  • NIR3
  • NIR3
  • NIR-3
  • RDGB2
  • RDGBA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.86
protein domain
0.73
cell line
0.68
cell type or tissue
0.63
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
2
2
5.9
93.5
1
1
0
1.1
87
2
2
2
86.9
2
2
0
1.1
75.6
BMI-adjusted hip circumference
1
1
2
49.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
5.9
93.5
0
1.1
87
2
86.9
0
1.1
75.6
BMI-adjusted hip circumference
2
49.9
Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PI
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PI
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (49)
1 – 10 of 49
VAPB
Tbio
Novelty: 0.00542377
p_int: 1
Score: 0.781
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.99984807
p_ni: 0.000018299
p_wrong: 0.000133631
Score: 0.792
Data Source: BioPlex,STRINGDB
PTK2B
Tclin
Family: Kinase
Novelty: 0.00174314
Score: 0.764
Data Source: STRINGDB
TXNDC12
Tbio
Novelty: 0.01354011
Score: 0.679
Data Source: STRINGDB
DAD1
Tbio
Family: Enzyme
Novelty: 0.00653242
Score: 0.652
Data Source: STRINGDB
SEC14L6
Tdark
Novelty: 0.45648697
Score: 0.627
Data Source: STRINGDB
EHD3
Tbio
Novelty: 0.02008691
Score: 0.609
Data Source: STRINGDB
DNASE2B
Tbio
Family: Enzyme
Novelty: 0.02506932
Score: 0.583
Data Source: STRINGDB
SEC14L4
Tbio
Novelty: 0.04131595
Score: 0.53
Data Source: STRINGDB
AP1G2
Tbio
Novelty: 0.17203425
Score: 0.52
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.87

PubMed score by year
PubTator Score  6.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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