Tbio DOCK9 Dedicator of cytokinesis protein 9

Protein Summary

Description

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.

Uniprot Accession IDs

• Q9BZ29
• B3KX25
• E9PFM9
• Q5JUD4
• Q5JUD6
• Q5T2Q1
• Q5TAN8
• Q9BZ25
• Q9BZ26
• Q9BZ27
• Q9BZ28
• Q9UPU4

Gene Name

• DOCK9

Ensembl ID

• ENST00000376460
• ENSP00000365643
• ENSG00000088387
• ENST00000627024
• ENSP00000487551

Symbol

• KIAA1058
• ZIZ1
• ZIZ1
• ZIZIMIN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
disease perturbation	0.95
transcription factor perturbation	0.91
histone modification site profile	0.89
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Dedicator Of Cytokinesis Protein 9

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Dedicator Of Cytokinesis Protein 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.17   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.17   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0