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Tbio
DOCK9
Dedicator of cytokinesis protein 9

Protein Summary
Description
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376460
  • ENSP00000365643
  • ENSG00000088387
  • ENST00000627024
  • ENSP00000487551

Symbol
  • KIAA1058
  • ZIZ1
  • ZIZ1
  • ZIZIMIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.95
transcription factor perturbation
0.91
histone modification site profile
0.89
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.78   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.78   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
DOCK10
Tbio
Novelty:  0.09286009
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  2e-9
Score:  0.697
Data Source:  BioPlex,STRINGDB
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.999999916
p_ni:  8.4e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.995
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.942
Data Source:  Reactome,STRINGDB
DHX8
Tbio
Family:  Enzyme
Novelty:  0.01584745
Score:  0.808
Data Source:  STRINGDB
DHX37
Tdark
Family:  Enzyme
Novelty:  0.02474351
Score:  0.8
Data Source:  STRINGDB
VSX1
Tbio
Family:  TF
Novelty:  0.01213324
Score:  0.676
Data Source:  STRINGDB
RHOF
Tbio
Family:  Enzyme
Novelty:  0.01795771
Score:  0.67
Data Source:  STRINGDB
ELMO1
Tbio
Novelty:  0.01598587
Score:  0.619
Data Source:  STRINGDB
RAB3GAP1
Tbio
Family:  Enzyme
Novelty:  0.0286836
Score:  0.614
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
7
97.7
1
1
0
1.4
61
FEV/FEC ratio
1
1
1
52.7
Cleft palate
1
1
0
1.3
52.7
leukocyte count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
7
97.7
0
1.4
61
FEV/FEC ratio
1
52.7
Cleft palate
0
1.3
52.7
leukocyte count
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 9
VGNC:5056
452635
Macaque
dedicator of cytokinesis 9
702426
Mouse
MGI:106321
105445
Rat
RGD:629617
259237
Dog
dedicator of cytokinesis 9
VGNC:40053
612820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 9
Macaque
dedicator of cytokinesis 9
Mouse
Rat
Dog
dedicator of cytokinesis 9
Publication Statistics
PubMed Score 12.78
PubMed score by year
PubTator Score 10.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title