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Tbio
DOCK9
Dedicator of cytokinesis protein 9

Protein Summary
Description
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376460
  • ENSP00000365643
  • ENSG00000088387
  • ENST00000627024
  • ENSP00000487551

Symbol
  • KIAA1058
  • ZIZ1
  • ZIZ1
  • ZIZIMIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.95
transcription factor perturbation
0.91
histone modification site profile
0.89
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.17   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.17   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0