ADAM33
Disintegrin and metalloproteinase domain-containing protein 33
Protein Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
- ENST00000350009
- ENSP00000322550
- ENSG00000149451
- ENST00000356518
- ENSP00000348912
- C20orf153
- C20orf153
- DJ964F7.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
ligand (protein) perturbation | 0.83 | ||
biological term | 0.71 | ||
tissue sample | 0.58 | ||
kinase perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 194.83 (req: < 5)
Gene RIFs: 123 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 194.83 (req: >= 5)
Gene RIFs: 123 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0