Tbio REG4 Regenerating islet-derived protein 4

Protein Summary

Description

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.

Uniprot Accession IDs

• Q9BYZ8
• Q8NER6
• Q8NER7
• REG-4

Gene Name

• REG4

Ensembl ID

• ENST00000256585
• ENSP00000256585
• ENSG00000134193
• ENST00000354219
• ENSP00000346158
• ENST00000369401
• ENSP00000358409

Symbol

• GISP
• RELP
• GISP
• RELP
• REG-IV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.65
biological term	0.59
cell line	0.58
protein domain	0.58
microRNA	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.23   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.23   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0