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Tbio
IFIH1
Interferon-induced helicase C domain-containing protein 1

Protein Summary
Description
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263642
  • ENSP00000263642
  • ENSG00000115267
  • ENST00000421365
  • ENSP00000408450
  • ENST00000649979
  • ENSP00000497271

Symbol
  • MDA5
  • RH116
  • AGS7
  • Hlcd
  • MDA5
  • MDA-5
  • RLR-2
  • IDDM19
  • SGMRT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
protein domain
0.92
histone modification site profile
0.89
gene perturbation
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1305.43   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1305.43   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0