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Tbio
IFIH1
Interferon-induced helicase C domain-containing protein 1

Protein Summary
Description
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263642
  • ENSP00000263642
  • ENSG00000115267
  • ENST00000421365
  • ENSP00000408450
  • ENST00000649979
  • ENSP00000497271

Symbol
  • MDA5
  • RH116
  • AGS7
  • Hlcd
  • MDA5
  • MDA-5
  • RLR-2
  • IDDM19
  • SGMRT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
protein domain
0.92
histone modification site profile
0.89
gene perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972   (req: < 5)
Gene RIFs: 186   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972   (req: >= 5)
Gene RIFs: 186   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
87.1
1
2
0
1.3
84
myeloid white cell count
1
1
1
76.9
autoimmune thyroid disease
1
2
0
1.2
69
1
1
0
1.4
68.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
87.1
0
1.3
84
myeloid white cell count
1
76.9
autoimmune thyroid disease
0
1.2
69
0
1.4
68.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced with helicase C domain 1
VGNC:1969
459692
Macaque
interferon induced with helicase C domain 1
702024
Mouse
MGI:1918836
71586
Rat
RGD:1560496
499801
Dog
interferon induced with helicase C domain 1
VGNC:41876
488371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced with helicase C domain 1
Macaque
interferon induced with helicase C domain 1
Mouse
Rat
Dog
interferon induced with helicase C domain 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYX4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
Immune System
Innate Immune System
Metabolism of proteins
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (287)
1 – 10 of 287
MPZL1
Tbio
Novelty: 0.03292508
p_int: 0.999995159
p_ni: 0.000004813
p_wrong: 2.8e-8
Score: 0.351
Data Source: BioPlex,STRINGDB
MAVS
Tbio
Novelty: 0.00241215
Score: 0.998
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.993
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.991
Data Source: Reactome,STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.982
Data Source: STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.982
Data Source: Reactome,STRINGDB
IKBKE
Tchem
Family: Kinase
Novelty: 0.01447079
Score: 0.979
Data Source: Reactome,STRINGDB
TRIM25
Tbio
Family: Enzyme
Novelty: 0.0045864
Score: 0.976
Data Source: STRINGDB
NLRC5
Tbio
Novelty: 0.01254197
Score: 0.974
Data Source: Reactome,STRINGDB
RNF125
Tbio
Family: Enzyme
Novelty: 0.07953156
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  972.00

PubMed score by year
PubTator Score  492.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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