TBC1D2
TBC1 domain family member 2A
Protein Summary
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
- ENST00000342112
- ENSP00000341567
- ENSG00000095383
- ENST00000375063
- ENSP00000364203
- ENST00000375064
- ENSP00000364205
- ENST00000375066
- ENSP00000364207
- ENST00000465784
- ENSP00000481721
- PARIS1
- PP8997
- TBC1D2A
- PARIS1
- PARIS-1
- TBC1D2A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.8 | ||
histone modification site profile | 0.78 | ||
tissue sample | 0.61 | ||
gene perturbation | 0.58 | ||
cell type or tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.93 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.93 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0