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Tbio
DEFB126
Beta-defensin 126

Protein Summary
Description
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569). Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382398
  • ENSP00000371835
  • ENSG00000125788

Symbol
  • C20orf8
  • DEFB26
  • HBD26
  • DEFB26
  • hBD-26
  • C20orf8
  • DEFB-26
  • bA530N10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.5
cell line
0.4
biological term
0.37
transcription factor
0.35
pathway
0.32


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 126
VGNC:6093
458023
Macaque
defensin beta 126
714089
Rat
RGD:708352
171412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 126
Macaque
defensin beta 126
Rat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYW3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (43)
1 – 10 of 43
DEFB114
Tbio
Novelty: 0.22206668
Score: 0.981
Data Source: STRINGDB
DEFB118
Tbio
Novelty: 0.14992977
Score: 0.973
Data Source: STRINGDB
DEFB127
Tbio
Novelty: 0.18126756
Score: 0.972
Data Source: STRINGDB
DEFB132
Tdark
Novelty: 0.43147041
Score: 0.972
Data Source: STRINGDB
DEFB128
Tbio
Novelty: 0.30093411
Score: 0.967
Data Source: STRINGDB
DEFB129
Tdark
Novelty: 0.26809608
Score: 0.966
Data Source: STRINGDB
DEFB125
Tdark
Novelty: 0.69005738
Score: 0.963
Data Source: STRINGDB
DEFB1
Tbio
Novelty: 0.00144458
Score: 0.955
Data Source: STRINGDB
DEFB110
Tdark
Novelty: 0.49548192
Score: 0.952
Data Source: STRINGDB
DEFB135
Tdark
Novelty: 2.04107063
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.98

PubMed score by year
PubTator Score  9.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer