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Tchem
SETD2
Histone-lysine N-methyltransferase SETD2

Protein Summary
Description
Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
biological process
0.86
histone modification site profile
0.74
protein domain
0.73
drug perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.36   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.36   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3414624
chemical structure image
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
85.6
myeloid white cell count
1
1
1
82.3
mean platelet volume
2
2
2
80.9
neutrophil count
2
2
2
77.9
macrophage inflammatory protein 1b measurement
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
85.6
myeloid white cell count
1
82.3
mean platelet volume
2
80.9
neutrophil count
2
77.9
macrophage inflammatory protein 1b measurement
1
66.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 2
VGNC:2562
460331
Macaque
SET domain containing 2
711825
Mouse
MGI:1918177
235626
Rat
RGD:1305576
316013
Dog
SET domain containing 2
VGNC:46054
476643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 2
Macaque
SET domain containing 2
Mouse
Rat
Dog
SET domain containing 2
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYW2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (349)
1 – 10 of 349
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.999999435
p_ni: 5.61e-7
p_wrong: 4e-9
Data Source: BioPlex
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.999990997
p_ni: 0.000009003
Score: 0.212
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.999974585
p_ni: 0.000025415
Score: 0.42
Data Source: BioPlex,STRINGDB
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.999924195
p_ni: 0.000075805
Score: 0.501
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999323898
p_ni: 0.000676102
Score: 0.302
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.997632246
p_ni: 0.002367754
Score: 0.16
Data Source: BioPlex,STRINGDB
HSPB8
Tbio
Novelty: 0.00298618
p_int: 0.989616618
p_ni: 0.010383382
Score: 0.181
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.987905474
p_ni: 0.012094131
p_wrong: 3.95e-7
Data Source: BioPlex
RSBN1
Tbio
Novelty: 0.1955858
p_int: 0.987699496
p_ni: 0.012300504
Score: 0.186
Data Source: BioPlex,STRINGDB
PSD2
Tdark
Novelty: 0.03272803
p_int: 0.986835179
p_ni: 0.013164795
p_wrong: 2.6e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  565.36

PubMed score by year
PubTator Score  328.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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