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Tbio
SLC2A11
Solute carrier family 2, facilitated glucose transporter member 11

Protein Summary
Description
Facilitative glucose transporter. This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316185
  • ENSP00000326748
  • ENSG00000133460
  • ENST00000345044
  • ENSP00000342542
  • ENST00000398356
  • ENSP00000381399
  • ENST00000618502
  • ENSP00000482495
  • ENSG00000275744
  • ENST00000619254
  • ENSP00000480839
  • ENST00000620942
  • ENSP00000483163

Symbol
  • GLUT10
  • GLUT11
  • GLUT10
  • GLUT11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
protein domain
0.58
tissue sample
0.58
tissue
0.57
transcription factor
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.48   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.48   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (26)
1 – 10 of 26
SLC5A1
Tclin
Family:  Transporter
Novelty:  0.00113611
Score:  0.593
Data Source:  STRINGDB
SLC5A2
Tclin
Family:  Transporter
Novelty:  0.00066797
Score:  0.566
Data Source:  STRINGDB
SLC26A11
Tdark
Family:  Transporter
Novelty:  0.0959704
Score:  0.532
Data Source:  STRINGDB
LRRC75B
Tdark
Novelty:  2.22222222
Score:  0.513
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.509
Data Source:  STRINGDB
SLC5A9
Tbio
Family:  Transporter
Novelty:  0.10768341
Score:  0.499
Data Source:  STRINGDB
SLC35E4
Tdark
Family:  Transporter
Novelty:  2.52316112
Score:  0.491
Data Source:  STRINGDB
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
Score:  0.483
Data Source:  STRINGDB
SLC7A13
Tdark
Family:  Transporter
Novelty:  0.20907223
Score:  0.481
Data Source:  STRINGDB
SLC15A2
Tchem
Family:  Transporter
Novelty:  0.00573108
Score:  0.476
Data Source:  STRINGDB
Pathways (5)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
SLC-mediated transmembrane transport
Transport of small molecules
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
6
5
3.7
96.9
serum gamma-glutamyl transferase measurement
3
6
5
3.7
96.9
serum IgG glycosylation measurement
1
1
1
82.8
serum IgG glycosylation measurement
1
1
1
82.8
serum non-albumin protein measurement
1
2
2
76.7
Items per page:
1 – 5 of 40
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
3.7
96.9
serum gamma-glutamyl transferase measurement
5
3.7
96.9
serum IgG glycosylation measurement
1
82.8
serum IgG glycosylation measurement
1
82.8
serum non-albumin protein measurement
2
76.7
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 11
VGNC:53405
458704
Macaque
Macrophage migration inhibitory factor [Source:UniProtKB/Swiss-Prot;Acc:Q6DN04]
Dog
solute carrier family 2 member 11
VGNC:52968
486405
Horse
solute carrier family 2 member 11 [Source:HGNC Symbol;Acc:HGNC:14239]
Cow
solute carrier family 2 member 11
VGNC:53922
615920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 11
Macaque
Macrophage migration inhibitory factor [Source:UniProtKB/Swiss-Prot;Acc:Q6DN04]
Dog
solute carrier family 2 member 11
Horse
solute carrier family 2 member 11 [Source:HGNC Symbol;Acc:HGNC:14239]
Cow
solute carrier family 2 member 11
Publication Statistics
PubMed Score 9.48
PubMed score by year
PubTator Score 9.00
PubTator score by year