Tbio BACH2 Transcription regulator protein BACH2

Protein Summary

Description

Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).

Uniprot Accession IDs

• Q9BYV9
• E1P518
• Q59H70
• Q5T793
• Q9NTS5

Gene Name

• BACH2

Ensembl ID

• ENST00000257749
• ENSP00000257749
• ENSG00000112182
• ENST00000343122
• ENSP00000345642
• ENST00000537989
• ENSP00000437473

Symbol

• BTBD25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
phenotype	0.88
PubMedID	0.88
protein domain	0.85
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.87   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.87   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0