CEP41
Centrosomal protein of 41 kDa
Protein Summary
Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
- ENST00000223208
- ENSP00000223208
- ENSG00000106477
- ENST00000343969
- ENSP00000342738
- ENST00000489512
- ENSP00000417815
- ENST00000541543
- ENSP00000445888
- ENST00000616628
- ENSP00000479252
- TSGA14
- JBTS15
- TSGA14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
histone modification site profile | 0.93 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.71 | ||
small molecule perturbation | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.74 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.74 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0