Tbio TRIM54 Tripartite motif-containing protein 54

Protein Summary

Description

May bind and stabilize microtubules during myotubes formation. The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BYV2
• A5D8T7
• Q53SY4
• Q9BYV3

Gene Name

• TRIM54

Ensembl ID

• ENST00000296098
• ENSP00000296098
• ENSG00000138100
• ENST00000380075
• ENSP00000369415

Symbol

• MURF
• MURF3
• RNF30
• MURF
• RNF30
• muRF3
• MURF-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
disease	0.61
molecular function	0.53
transcription factor	0.5
tissue	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.05   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 318   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.05   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0