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Tbio
TRIM54
Tripartite motif-containing protein 54

Protein Summary
Description
May bind and stabilize microtubules during myotubes formation. The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296098
  • ENSP00000296098
  • ENSG00000138100
  • ENST00000380075
  • ENSP00000369415

Symbol
  • MURF
  • MURF3
  • RNF30
  • MURF
  • RNF30
  • muRF3
  • MURF-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
disease
0.61
molecular function
0.53
transcription factor
0.5
tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.9   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.9   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (43)
1 – 10 of 43
CAVIN4
Tbio
Novelty: 0.03177065
Score: 0.747
Data Source: STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
Score: 0.716
Data Source: STRINGDB
FBXO32
Tbio
Novelty: 0.00225437
Score: 0.706
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.622
Data Source: STRINGDB
FLNC
Tbio
Novelty: 0.00463205
Score: 0.6
Data Source: STRINGDB
NBR1
Tbio
Novelty: 0.00893066
Score: 0.597
Data Source: STRINGDB
CKM
Tbio
Family: Kinase
Novelty: 0.00239628
Score: 0.591
Data Source: STRINGDB
TRIM66
Tbio
Family: Epigenetic
Novelty: 0.20544697
Score: 0.587
Data Source: STRINGDB
TCAP
Tbio
Novelty: 0.00623581
Score: 0.558
Data Source: STRINGDB
ALAD
Tbio
Family: Enzyme
Novelty: 0.00092757
Score: 0.558
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.90

PubMed score by year
PubTator Score  20.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer