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Tbio
AGXT2
Alanine--glyoxylate aminotransferase 2, mitochondrial

Protein Summary
Description
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231420
  • ENSP00000231420
  • ENSG00000113492
  • ENST00000510428
  • ENSP00000422799
  • ENST00000618015
  • ENSP00000479154

Symbol
  • AGT2
  • AGT2
  • BAIBA
  • DAIBAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.72
gene perturbation
0.68
cell line
0.62
protein domain
0.58
phenotype
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.59   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.59   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
4
11
97.1
symmetrical dimethylarginine measurement
1
1
1
93.4
1
1
1
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
11
97.1
symmetrical dimethylarginine measurement
1
93.4
1
87.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alanine--glyoxylate aminotransferase 2
VGNC:6376
471573
Macaque
alanine--glyoxylate aminotransferase 2
699250
Mouse
MGI:2146052
268782
Rat
RGD:621767
83784
Dog
alanine--glyoxylate aminotransferase 2
VGNC:50868
612589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alanine--glyoxylate aminotransferase 2
Macaque
alanine--glyoxylate aminotransferase 2
Mouse
Rat
Dog
alanine--glyoxylate aminotransferase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYV1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of nucleotides
Nucleobase catabolism
Protein-Protein Interactions (113)
1 – 10 of 113
UPB1
Tbio
Family: Enzyme
Novelty: 0.01797327
Score: 0.985
Data Source: STRINGDB
AGXT
Tbio
Family: Enzyme
Novelty: 0.00267512
Score: 0.984
Data Source: STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
Score: 0.964
Data Source: STRINGDB
HIBADH
Tbio
Family: Enzyme
Novelty: 0.03861647
Score: 0.953
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.943
Data Source: STRINGDB
GATM
Tbio
Family: Enzyme
Novelty: 0.00340356
Score: 0.938
Data Source: STRINGDB
ALDH6A1
Tbio
Family: Enzyme
Novelty: 0.03785268
Score: 0.937
Data Source: STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.93
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.93
Data Source: STRINGDB
ABAT
Tclin
Family: Enzyme
Novelty: 0.0078359
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.59

PubMed score by year
PubTator Score  25.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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