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Tbio
ANO3
Anoctamin-3

Protein Summary
Description
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256737
  • ENSP00000256737
  • ENSG00000134343
  • ENST00000531568
  • ENSP00000432394

Symbol
  • C11orf25
  • TMEM16C
  • DYT23
  • DYT24
  • TMEM16C
  • C11orf25
  • GENX-3947
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
gene perturbation
0.74
molecular function
0.73
microRNA
0.66
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.89   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.89   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
GNAL
Tbio
Novelty:  0.01757098
Score:  0.795
Data Source:  STRINGDB
CIZ1
Tbio
Novelty:  0.03730538
Score:  0.793
Data Source:  STRINGDB
THAP1
Tbio
Family:  TF
Novelty:  0.00785951
Score:  0.732
Data Source:  STRINGDB
PLSCR5
Tdark
Family:  Enzyme
Novelty:  1.58520094
Score:  0.693
Data Source:  STRINGDB
PLSCR2
Tdark
Family:  Enzyme
Novelty:  0.3663297
Score:  0.677
Data Source:  STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.669
Data Source:  STRINGDB
TOR1A
Tbio
Novelty:  0.00056274
Score:  0.669
Data Source:  STRINGDB
PLSCR4
Tbio
Family:  Enzyme
Novelty:  0.12079798
Score:  0.666
Data Source:  STRINGDB
SGCE
Tbio
Novelty:  0.00449577
Score:  0.642
Data Source:  STRINGDB
TUBB4A
Tclin
Novelty:  0.00045092
Score:  0.624
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Febrile seizure (within the age range of 3 months to 6 years)
2
1
0
2.1
72.5
waist-hip ratio
1
2
2
55.8
MMR-related febrile seizures
1
1
0
2.1
54.4
BMI-adjusted waist-hip ratio
2
2
3
54.2
sex hormone-binding globulin measurement
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Febrile seizure (within the age range of 3 months to 6 years)
0
2.1
72.5
waist-hip ratio
2
55.8
MMR-related febrile seizures
0
2.1
54.4
BMI-adjusted waist-hip ratio
3
54.2
sex hormone-binding globulin measurement
2
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anoctamin 3
VGNC:3218
735375
Macaque
anoctamin 3
700072
Mouse
MGI:3613666
228432
Rat
RGD:1308873
311287
Dog
anoctamin 3
VGNC:37926
476892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anoctamin 3
Macaque
anoctamin 3
Mouse
Rat
Dog
anoctamin 3
Publication Statistics
PubMed Score 47.89
PubMed score by year
PubTator Score 20.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title