Protein Summary
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channe ...more
- ENST00000256737
- ENSP00000256737
- ENSG00000134343
- ENST00000531568
- ENSP00000432394
- C11orf25
- TMEM16C
- DYT23
- DYT24
- TMEM16C
- C11orf25
- GENX-3947
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.99 | ||
gene perturbation | 0.74 | ||
molecular function | 0.73 | ||
microRNA | 0.66 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.89 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 103 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.89 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 103 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Febrile seizure (within the age range of 3 months to 6 years) | 2 | 1 | 0 | 2.1 | 72.5 | ||||
waist-hip ratio | 1 | 2 | 2 | 55.8 | |||||
MMR-related febrile seizures | 1 | 1 | 0 | 2.1 | 54.4 | ||||
BMI-adjusted waist-hip ratio | 2 | 2 | 3 | 54.2 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 44.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Febrile seizure (within the age range of 3 months to 6 years) | 0 | 2.1 | 72.5 | ||||
waist-hip ratio | 2 | 55.8 | |||||
MMR-related febrile seizures | 0 | 2.1 | 54.4 | ||||
BMI-adjusted waist-hip ratio | 3 | 54.2 | |||||
sex hormone-binding globulin measurement | 2 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | anoctamin 3 | VGNC:3218 | 735375 | |||||
Macaque | anoctamin 3 | 700072 | ||||||
Mouse | MGI:3613666 | 228432 | ||||||
Rat | RGD:1308873 | 311287 | ||||||
Dog | anoctamin 3 | VGNC:37926 | 476892 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | anoctamin 3 | |||||
Macaque | anoctamin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | anoctamin 3 | |||||
Publication Statistics
PubMed Score 47.89
PubMed score by year
PubTator Score 20.75
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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