You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NLN
Neurolysin, mitochondrial

Protein Summary
Description
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380985
  • ENSP00000370372
  • ENSG00000123213

Symbol
  • AGTBP
  • KIAA1226
  • MEP
  • MOP
  • AGTBP
  • EP24.16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.86
microRNA
0.85
virus perturbation
0.83
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.64   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.64   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
1
1
0
8.2
66.8
daytime rest measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
0
8.2
66.8
daytime rest measurement
1
28.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurolysin
VGNC:7091
461840
Macaque
neurolysin
696884
Mouse
MGI:1923055
75805
Rat
RGD:621518
117041
Dog
neurolysin
VGNC:43842
478081
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurolysin
Macaque
neurolysin
Mouse
Rat
Dog
neurolysin
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYT8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
LDLRAP1
Tbio
Novelty:  0.0150723
p_int:  0.999951303
p_ni:  0.000048697
Score:  0.381
Data Source:  BioPlex,STRINGDB
GPRIN3
Tbio
Novelty:  0.15509625
p_int:  0.995951872
p_ni:  0.004048128
p_wrong:  1e-9
Data Source:  BioPlex
MBP
Tbio
Novelty:  0.00016333
p_int:  0.973146809
p_ni:  0.026853139
p_wrong:  5.3e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.960148768
p_ni:  0.039851209
p_wrong:  2.4e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.932218323
p_ni:  0.067781677
Data Source:  BioPlex
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.885871894
p_ni:  0.1141281
p_wrong:  7e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
p_int:  0.776362261
p_ni:  0.223637739
Score:  0.345
Data Source:  BioPlex,STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
p_int:  0.762526616
p_ni:  0.237473358
p_wrong:  2.6e-8
Data Source:  BioPlex
NTS
Tbio
Novelty:  0.00033201
Score:  0.975
Data Source:  Reactome,STRINGDB
PITRM1
Tchem
Family:  Enzyme
Novelty:  0.08067518
Score:  0.772
Data Source:  STRINGDB
Publication Statistics
PubMed Score  87.64

PubMed score by year
PubTator Score  151.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: