Tbio NLN Neurolysin, mitochondrial

Protein Summary

Description

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q9BYT8
• Q9ULJ4

Gene Name

• NLN

Ensembl ID

• ENST00000380985
• ENSP00000370372
• ENSG00000123213

Symbol

• AGTBP
• KIAA1226
• MEP
• MOP
• AGTBP
• EP24.16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.86
microRNA	0.85
virus perturbation	0.83
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Neurolysin, Mitochondrial

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Neurolysin, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.02   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.02   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0