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Tchem
STK33
Serine/threonine-protein kinase 33

Protein Summary
Description
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315204
  • ENSP00000320754
  • ENSG00000130413
  • ENST00000396672
  • ENSP00000379905
  • ENST00000447869
  • ENSP00000416750
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
histone modification site profile
0.78
interacting protein
0.62
microRNA
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.78   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.78   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1