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Tchem
STK33
Serine/threonine-protein kinase 33

Protein Summary
Description
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315204
  • ENSP00000320754
  • ENSG00000130413
  • ENST00000396672
  • ENSP00000379905
  • ENST00000447869
  • ENSP00000416750
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
histone modification site profile
0.78
interacting protein
0.62
microRNA
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.05   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.05   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
69.6
body height
1
1
1
40.7
alcohol use disorder measurement
1
1
1
5.2
alcohol consumption measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
69.6
body height
1
40.7
alcohol use disorder measurement
1
5.2
alcohol consumption measurement
1
5.2
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
FAM167B
Tdark
Novelty: 1.52643914
Score: 0.8
Data Source: STRINGDB
KCNS2
Tclin
Family: IC
Novelty: 0.51090552
Score: 0.723
Data Source: STRINGDB
ZCCHC14
Tbio
Novelty: 0.18393973
Score: 0.71
Data Source: STRINGDB
RRAS2
Tbio
Family: Enzyme
Novelty: 0.01870067
Score: 0.705
Data Source: STRINGDB
PSMA1
Tclin
Family: Enzyme
Novelty: 0.013722
Score: 0.686
Data Source: STRINGDB
INSC
Tbio
Novelty: 0.01752306
Score: 0.663
Data Source: STRINGDB
ST5
Tbio
Novelty: 0.0046113
Score: 0.657
Data Source: STRINGDB
PDLIM4
Tbio
Novelty: 0.01308013
Score: 0.652
Data Source: STRINGDB
FCRL6
Tbio
Novelty: 0.19257954
Score: 0.631
Data Source: STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
Score: 0.628
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.05

PubMed score by year
PubTator Score  14.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer