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Tdark
KRTAP4-2
Keratin-associated protein 4-2

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377726
  • ENSP00000366955
  • ENSG00000244537

Symbol
  • KAP4.2
  • KRTAP4.2
  • KAP4.2
  • KRTAP4.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
cell line
0.54
tissue
0.44
microRNA
0.38
transcription factor
0.31


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (58)
1 – 10 of 58
CYP21A2
Tchem
Family: Enzyme
Novelty: 0.00110959
Score: 0.671
Data Source: STRINGDB
KRTAP12-1
Tdark
Novelty: 0.59243755
Score: 0.601
Data Source: STRINGDB
KRTAP17-1
Tdark
Novelty: 2.798404
Score: 0.576
Data Source: STRINGDB
KRTAP26-1
Tdark
Novelty: 0.48053029
Score: 0.566
Data Source: STRINGDB
KRTAP5-2
Tdark
Novelty: 3.93025514
Score: 0.553
Data Source: STRINGDB
KRTAP3-3
Tdark
Novelty: 1.72994972
Score: 0.553
Data Source: STRINGDB
KRTAP11-1
Tbio
Novelty: 0.20865014
Score: 0.543
Data Source: STRINGDB
KRTAP5-9
Tdark
Novelty: 0.13336736
Score: 0.538
Data Source: STRINGDB
KRTAP3-1
Tdark
Novelty: 1.73340145
Score: 0.531
Data Source: STRINGDB
KRTAP5-7
Tdark
Novelty: 3.45402383
Score: 0.529
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.55

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer