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Tbio
KRTAP4-3
Keratin-associated protein 4-3

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391356
  • ENSP00000375151
  • ENSG00000196156

Symbol
  • KAP4.3
  • KRTAP4.3
  • KAP4.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
cell line
0.5
microRNA
0.32
tissue
0.29
PubMedID
0.28


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (64)
1 – 10 of 64
KRTAP3-1
Tdark
Score: 0.61
Data Source: STRINGDB
KRTAP24-1
Tdark
Novelty: 0.56074766
Score: 0.604
Data Source: STRINGDB
KRTAP7-1
Tdark
Novelty: 0.3125
Score: 0.592
Data Source: STRINGDB
KRTAP17-1
Tdark
Novelty: 4
Score: 0.587
Data Source: STRINGDB
KRT38
Tdark
Novelty: 0.35478736
Score: 0.585
Data Source: STRINGDB
KRTAP13-3
Tdark
Novelty: 2.5
Score: 0.578
Data Source: STRINGDB
KRTAP22-1
Tdark
Novelty: 0.75
Score: 0.578
Data Source: STRINGDB
KRTAP6-2
Tdark
Novelty: 1.42857143
Score: 0.575
Data Source: STRINGDB
KRTAP3-3
Tdark
Novelty: 2
Score: 0.57
Data Source: STRINGDB
KRT27
Tdark
Novelty: 0.485598
Score: 0.569
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.08

PubMed score by year
PubTator Score  0.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer