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Tbio
KRTAP4-5
Keratin-associated protein 4-5

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343246
  • ENSP00000340546
  • ENSG00000198271

Symbol
  • KAP4.5
  • KRTAP4.5
  • KAP4.5
  • KRTAP4.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.57
cell line
0.48
tissue sample
0.37
microRNA
0.36
phenotype
0.36


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.24   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 1   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.24   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
40.5
hair shape measurement
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
40.5
hair shape measurement
1
5.6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYR2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
KRTAP12-1
Tdark
Novelty:  0.59243755
Score:  0.607
Data Source:  STRINGDB
KRTAP27-1
Tdark
Novelty:  0.72484342
Score:  0.567
Data Source:  STRINGDB
ZNF772
Tdark
Family:  TF
Novelty:  0.71750685
Score:  0.556
Data Source:  STRINGDB
KRTAP26-1
Tdark
Novelty:  0.48053029
Score:  0.553
Data Source:  STRINGDB
KRTAP5-2
Tdark
Novelty:  3.93025514
Score:  0.543
Data Source:  STRINGDB
KRTAP1-4
Tdark
Novelty:  0.44744505
Score:  0.528
Data Source:  STRINGDB
KRTAP20-1
Tdark
Novelty:  0.5308345
Score:  0.525
Data Source:  STRINGDB
KRTAP5-9
Tdark
Novelty:  0.13336736
Score:  0.518
Data Source:  STRINGDB
KRTAP15-1
Tdark
Novelty:  1.11971653
Score:  0.514
Data Source:  STRINGDB
ERICH6B
Tdark
Novelty:  1.91675016
Score:  0.511
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.24

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer