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Tbio
KRTAP4-7
Keratin-associated protein 4-7

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391417
  • ENSP00000375236
  • ENSG00000240871

Symbol
  • KAP4.7
  • KRTAP4.7
  • KAP4.7
  • KRTAP4-7
  • KRTAP4.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.5
microRNA
0.38
tissue
0.38
cell type or tissue
0.37
gene perturbation
0.25


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
DEFB115
Tdark
Novelty:  0.51464209
Score:  0.571
Data Source:  STRINGDB
KRTAP12-1
Tdark
Novelty:  0.59243755
Score:  0.519
Data Source:  STRINGDB
KRTAP3-3
Tdark
Novelty:  1.72994972
Score:  0.5
Data Source:  STRINGDB
KRTAP3-2
Tdark
Novelty:  1.99836821
Score:  0.494
Data Source:  STRINGDB
DEFB130A
Tbio
Novelty:  0.56664969
Score:  0.48
Data Source:  STRINGDB
CLCC1
Tbio
Family:  IC
Novelty:  0.06584842
Score:  0.463
Data Source:  STRINGDB
KRT33B
Tbio
Novelty:  0.43947743
Score:  0.456
Data Source:  STRINGDB
KRTAP6-1
Tdark
Novelty:  0.3016588
Score:  0.454
Data Source:  STRINGDB
KRT73
Tdark
Novelty:  0.36334003
Score:  0.445
Data Source:  STRINGDB
KRTAP5-4
Tdark
Novelty:  0.40323321
Score:  0.444
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
40.5
hair shape measurement
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
40.5
hair shape measurement
1
5.6
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 0.06
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title