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Tbio
KRTAP4-9
Keratin-associated protein 4-9

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391415
  • ENSP00000375234
  • ENSG00000212722

Symbol
  • KAP4.9
  • KRTAP4.9
  • KAP4.9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.89
microRNA
0.63
cell line
0.55
gene perturbation
0.44
transcription factor
0.25


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYQ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (62)
1 – 10 of 62
KRTAP17-1
Tdark
Novelty: 2.798404
Score: 0.582
Data Source: STRINGDB
KRTAP3-1
Tdark
Novelty: 1.73340145
Score: 0.562
Data Source: STRINGDB
SLC35G6
Tdark
Family: Transporter
Novelty: 3.2415685
Score: 0.526
Data Source: STRINGDB
POTEC
Tdark
Novelty: 1.98957109
Score: 0.517
Data Source: STRINGDB
KRTAP27-1
Tdark
Novelty: 0.72484342
Score: 0.504
Data Source: STRINGDB
KRTAP2-2
Tdark
Novelty: 3.83376619
Score: 0.498
Data Source: STRINGDB
KRTAP12-1
Tdark
Novelty: 0.59243755
Score: 0.493
Data Source: STRINGDB
KRT79
Tbio
Novelty: 0.07935891
Score: 0.491
Data Source: STRINGDB
KRTAP15-1
Tdark
Novelty: 1.11971653
Score: 0.485
Data Source: STRINGDB
KRT27
Tdark
Novelty: 0.34729004
Score: 0.48
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.06

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer