Pharos : Target Details

Tdark

Protein Summary

Description

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, ...more

Uniprot Accession IDs

Gene Name

KRTAP4-11

Ensembl ID

ENST00000391413
ENSP00000375232
ENSG00000212721
ENST00000573418
ENSP00000460506
ENSG00000263229

Symbol

KAP4.14
KRTAP4-14
KRTAP4.11
KRTAP4.14
KAP4.11
KAP4.14
KRTAP4-14
KRTAP4.14

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.54

microRNA	0.52

cellular component	0.46

cell type or tissue	0.41

cell line	0.39

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.14 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 0 (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.14 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 0 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen