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Tbio
SRXN1
Sulfiredoxin-1

Protein Summary
Description
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381962
  • ENSP00000371388
  • ENSG00000271303

Symbol
  • C20orf139
  • SRX
  • SRX1
  • SRX
  • Npn3
  • SRX1
  • C20orf139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.91
histone modification site profile
0.86
molecular function
0.86
small molecule perturbation
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.78   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.78   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
NRF2 pathway
WikiPathways
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
Name
Explore in Pharos
Explore in Source
Nuclear Receptors Meta-Pathway
NRF2 pathway
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
Protein-Protein Interactions (104)
1 – 10 of 104
PRDX1
Tbio
Novelty: 0.00234504
Score: 0.982
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00056085
Score: 0.891
Data Source: STRINGDB
PIR
Tbio
Novelty: 0.00155612
Score: 0.874
Data Source: STRINGDB
PRDX6
Tbio
Novelty: 0.00188945
Score: 0.84
Data Source: STRINGDB
TRIP6
Tbio
Novelty: 0.03035413
Score: 0.831
Data Source: STRINGDB
TTLL12
Tbio
Family: Enzyme
Novelty: 0.19565217
Score: 0.826
Data Source: STRINGDB
TTC9C
Tdark
Novelty: 10
Score: 0.825
Data Source: STRINGDB
ZRANB2
Tbio
Novelty: 0.02084407
Score: 0.825
Data Source: STRINGDB
UBA2
Tbio
Novelty: 0.02816874
Score: 0.825
Data Source: STRINGDB
TTC1
Tbio
Novelty: 0.02687059
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.78

PubMed score by year
PubTator Score  58.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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