You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SRXN1
Sulfiredoxin-1

Protein Summary
Description
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381962
  • ENSP00000371388
  • ENSG00000271303

Symbol
  • C20orf139
  • SRX
  • SRX1
  • SRX
  • Npn3
  • SRX1
  • C20orf139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.91
histone modification site profile
0.86
molecular function
0.86
small molecule perturbation
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.71   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.71   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104971
76650
Dog
sulfiredoxin 1
VGNC:46822
100686728
Cow
sulfiredoxin 1
VGNC:35304
531606
Pig
sulfiredoxin 1
100517736
Opossum
sulfiredoxin 1
100012125
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
sulfiredoxin 1
Cow
sulfiredoxin 1
Pig
sulfiredoxin 1
Opossum
sulfiredoxin 1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
NRF2 pathway
WikiPathways
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
Name
Explore in Pharos
Explore in Source
Nuclear Receptors Meta-Pathway
NRF2 pathway
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
Protein-Protein Interactions (104)
1 – 10 of 104
PRDX1
Tbio
Novelty: 0.00207935
Score: 0.982
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.891
Data Source: STRINGDB
PIR
Tbio
Novelty: 0.00327695
Score: 0.874
Data Source: STRINGDB
PRDX6
Tbio
Novelty: 0.00180564
Score: 0.84
Data Source: STRINGDB
TRIP6
Tbio
Novelty: 0.02183202
Score: 0.831
Data Source: STRINGDB
TTLL12
Tbio
Family: Enzyme
Novelty: 0.12652318
Score: 0.826
Data Source: STRINGDB
TTC9C
Tdark
Novelty: 0.85949913
Score: 0.825
Data Source: STRINGDB
ZRANB2
Tbio
Novelty: 0.06105086
Score: 0.825
Data Source: STRINGDB
UBA2
Tbio
Novelty: 0.01582807
Score: 0.825
Data Source: STRINGDB
TTC1
Tbio
Novelty: 0.01389711
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  147.71

PubMed score by year
PubTator Score  58.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer