Tbio SRXN1 Sulfiredoxin-1

Protein Summary

Description

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Uniprot Accession IDs

• Q9BYN0
• B2R543
• Q8NDM3
• Q96AK6

Gene Name

• SRXN1

Ensembl ID

• ENST00000381962
• ENSP00000371388
• ENSG00000271303

Symbol

• C20orf139
• SRX
• SRX1
• SRX
• Npn3
• SRX1
• C20orf139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.91
histone modification site profile	0.86
molecular function	0.86
small molecule perturbation	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.78   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.78   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0