Tbio RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1

Protein Summary

Description

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BYM8
• O95623
• Q86SL2
• Q96BS3
• Q9BYM9

Gene Name

• RBCK1

Ensembl ID

• ENST00000353660
• ENSP00000254960
• ENSG00000125826
• ENST00000356286
• ENSP00000348632

Symbol

• C20orf18
• RNF54
• UBCE7IP3
• XAP3
• XAP4
• XAP3
• XAP4
• HOIL1
• PBMEI
• PGBM1
• RBCK2
• RNF54
• HOIL-1
• ZRANB4
• C20orf18
• UBCE7IP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.88
biological process	0.87
disease perturbation	0.79
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Ranbp-type And C3hc4-type Zinc Finger-containing Protein 1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Ranbp-type And C3hc4-type Zinc Finger-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.81   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.81   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0