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Tbio
RBCK1
RanBP-type and C3HC4-type zinc finger-containing protein 1

Protein Summary
Description
E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353660
  • ENSP00000254960
  • ENSG00000125826
  • ENST00000356286
  • ENSP00000348632

Symbol
  • C20orf18
  • RNF54
  • UBCE7IP3
  • XAP3
  • XAP4
  • XAP3
  • XAP4
  • HOIL1
  • PBMEI
  • PGBM1
  • RBCK2
  • RNF54
  • HOIL-1
  • ZRANB4
  • C20orf18
  • UBCE7IP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.88
biological process
0.87
disease perturbation
0.79
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.81   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.81   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (330)
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.999999994
p_ni:  6e-9
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999997922
p_ni:  0.000002078
Data Source:  BioPlex
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.999993431
p_ni:  6.8e-8
p_wrong:  0.000006501
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
FKBPL
Tbio
Novelty:  0.02054842
p_int:  0.999954158
p_ni:  0.000037712
p_wrong:  0.000008129
Score:  0.765
Data Source:  BioPlex,STRINGDB
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999885966
p_ni:  0.000113984
p_wrong:  5e-8
Score:  0.231
Data Source:  BioPlex,STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.999756934
p_ni:  0.000243048
p_wrong:  1.7e-8
Score:  0.428
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.999523783
p_ni:  0.000260632
p_wrong:  0.000215586
Data Source:  BioPlex
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999322464
p_ni:  0.000677008
p_wrong:  5.28e-7
Score:  0.217
Data Source:  BioPlex,STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
p_int:  0.999241308
p_ni:  0.000743445
p_wrong:  0.000015247
Score:  0.163
Data Source:  BioPlex,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.993
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (44)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Death Receptor Signalling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Death Receptor Signalling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
57.3
gut microbiome measurement
1
1
1
21.2
eosinophil count
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
57.3
gut microbiome measurement
1
21.2
eosinophil count
1
4.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RANBP2-type and C3HC4-type zinc finger containing 1
VGNC:9966
458025
Macaque
RANBP2-type and C3HC4-type zinc finger containing 1
714692
Mouse
MGI:1344372
24105
Rat
RGD:708404
60383
Dog
RANBP2-type and C3HC4-type zinc finger containing 1
VGNC:45397
485818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RANBP2-type and C3HC4-type zinc finger containing 1
Macaque
RANBP2-type and C3HC4-type zinc finger containing 1
Mouse
Rat
Dog
RANBP2-type and C3HC4-type zinc finger containing 1
Publication Statistics
PubMed Score 53.81
PubMed score by year
PubTator Score 26.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title