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Tbio
FGFBP2
Fibroblast growth factor-binding protein 2

Protein Summary
Description
This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259989
  • ENSP00000259989
  • ENSG00000137441

Symbol
  • KSP37
  • KSP37
  • HBP17RP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.59
tissue
0.4
cell line
0.36
virus perturbation
0.36
microRNA
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
FGF22
Tbio
Novelty:  0.0553003
Score:  0.932
Data Source:  STRINGDB
FGF7
Tbio
Novelty:  0.00083346
Score:  0.931
Data Source:  STRINGDB
FGF10
Tbio
Novelty:  0.00217451
Score:  0.928
Data Source:  STRINGDB
FGF3
Tbio
Novelty:  0.00474087
Score:  0.913
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.911
Data Source:  STRINGDB
FGF1
Tchem
Novelty:  0.00055979
Score:  0.906
Data Source:  STRINGDB
SERAC1
Tbio
Novelty:  0.04211159
Score:  0.65
Data Source:  STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
Score:  0.633
Data Source:  STRINGDB
CILP2
Tbio
Novelty:  0.07992715
Score:  0.615
Data Source:  STRINGDB
GNLY
Tbio
Novelty:  0.00183877
Score:  0.526
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
FGFR2 ligand binding and activation (R-HSA-190241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 ligand binding and activation
Reactome
FGFR2b ligand binding and activation
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Name
Explore in Pharos
Explore in Source
FGFR2 ligand binding and activation
FGFR2b ligand binding and activation
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
2
3
50.4
pulse pressure measurement
1
1
1
44.2
electrocardiography
1
1
4
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
50.4
pulse pressure measurement
1
44.2
electrocardiography
4
33.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor binding protein 2
VGNC:10862
471150
Macaque
fibroblast growth factor binding protein 2
714554
Opossum
fibroblast growth factor binding protein 2
100015548
Chicken
fibroblast growth factor binding protein 2
CGNC:10779
395094
Anole lizard
fibroblast growth factor binding protein 2
103278728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor binding protein 2
Macaque
fibroblast growth factor binding protein 2
Opossum
fibroblast growth factor binding protein 2
Chicken
fibroblast growth factor binding protein 2
Anole lizard
fibroblast growth factor binding protein 2
Publication Statistics
PubMed Score 7.77
PubMed score by year
PubTator Score 6.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title