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Tbio
NFKBIZ
NF-kappa-B inhibitor zeta

Protein Summary
Description
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). This gene is a member of the ankyrin-repeat family and is induce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326151
  • ENSP00000325593
  • ENSG00000144802
  • ENST00000326172
  • ENSP00000325663
  • ENST00000394054
  • ENSP00000377618

Symbol
  • IKBZ
  • INAP
  • MAIL
  • IKBZ
  • INAP
  • MAIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
histone modification site profile
0.84
PubMedID
0.83
gene perturbation
0.78
transcription factor
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.85   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.85   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.908
Data Source:  STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.861
Data Source:  STRINGDB
HRASLS5
Tchem
Family:  Enzyme
Novelty:  0.02885442
Score:  0.79
Data Source:  STRINGDB
ZC3H12A
Tbio
Family:  Enzyme
Novelty:  0.00651373
Score:  0.721
Data Source:  STRINGDB
TNFAIP3
Tbio
Novelty:  0.00257088
Score:  0.716
Data Source:  STRINGDB
MAP3K8
Tchem
Family:  Kinase
Novelty:  0.00581582
Score:  0.675
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.671
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.66
Data Source:  STRINGDB
IL17A
Tclin
Novelty:  0.00011583
Score:  0.593
Data Source:  STRINGDB
CXCL2
Tbio
Novelty:  0.00201175
Score:  0.59
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
68.5
serum non-albumin protein measurement
1
1
1
64.7
psoriasis vulgaris
1
1
0
1.2
29.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
68.5
serum non-albumin protein measurement
1
64.7
psoriasis vulgaris
0
1.2
29.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor zeta
VGNC:8840
460564
Macaque
NFKB inhibitor zeta
702846
Mouse
MGI:1931595
80859
Rat
RGD:1310834
304005
Dog
NFKB inhibitor zeta
VGNC:43785
478549
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor zeta
Macaque
NFKB inhibitor zeta
Mouse
Rat
Dog
NFKB inhibitor zeta
Publication Statistics
PubMed Score 402.85
PubMed score by year
PubTator Score 75.15
PubTator score by year
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Related Publications
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PMID
Year
Title