Protein Summary
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).
- ENST00000276708
- ENSP00000276708
- ENSG00000147697
- ENST00000619643
- ENSP00000482343
- MLZE
- MLZE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.75 | ||
kinase perturbation | 0.66 | ||
tissue sample | 0.57 | ||
cellular component | 0.48 | ||
transcription factor | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.28 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.28 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0