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Tbio
PARD6B
Partitioning defective 6 homolog beta

Protein Summary
Description
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371610
  • ENSP00000360672
  • ENSG00000124171
  • ENST00000396039
  • ENSP00000379354

Symbol
  • PAR6B
  • PAR6B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
transcription factor perturbation
0.8
histone modification site profile
0.79
virus perturbation
0.79
transcription factor
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.97   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.97   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
68.2
keratinocyte carcinoma
1
1
0
1.1
12.4
1
1
0
1.1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
68.2
keratinocyte carcinoma
0
1.1
12.4
0
1.1
6.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
par-6 family cell polarity regulator beta
712004
Mouse
MGI:2135605
58220
Rat
RGD:1308205
362279
Dog
par-6 family cell polarity regulator beta
VGNC:54725
485926
Horse
par-6 family cell polarity regulator beta
VGNC:21163
100052187
Species
Name
OMA
EggNOG
Inparanoid
Macaque
par-6 family cell polarity regulator beta
Mouse
Rat
Dog
par-6 family cell polarity regulator beta
Horse
par-6 family cell polarity regulator beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYG5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (66)
1 – 10 of 66
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
PARD3
Tbio
Novelty:  0.00521327
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PTPN21
Tbio
Family:  Enzyme
Novelty:  0.07773004
p_int:  0.999999959
p_ni:  2.4e-8
p_wrong:  1.7e-8
Score:  0.351
Data Source:  BioPlex,STRINGDB
WWC1
Tbio
Novelty:  0.00905646
p_int:  0.999999698
p_ni:  2.68e-7
p_wrong:  3.4e-8
Score:  0.852
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999999664
p_ni:  3.36e-7
Data Source:  BioPlex
LLGL1
Tbio
Novelty:  0.01591552
p_int:  0.999917843
p_ni:  0.000082157
Score:  0.975
Data Source:  BioPlex,STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
p_int:  0.99943962
p_ni:  0.000548341
p_wrong:  0.000012039
Score:  0.725
Data Source:  BioPlex,STRINGDB
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
p_int:  0.993313228
p_ni:  0.006686772
Score:  0.295
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.97

PubMed score by year
PubTator Score  7.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer