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Tbio
PARD6G
Partitioning defective 6 homolog gamma

Protein Summary
Description
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353265
  • ENSP00000343144
  • ENSG00000178184
  • ENST00000470488
  • ENSP00000468735

Symbol
  • PAR6G
  • PAR-6G
  • PAR6gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.69
disease perturbation
0.68
small molecule perturbation
0.53
histone modification site profile
0.51
hub protein
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.999999829
p_ni:  1.56e-7
p_wrong:  1.5e-8
Score:  0.941
Data Source:  BioPlex,STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
p_int:  0.999656778
p_ni:  1.3e-8
p_wrong:  0.000343209
Score:  0.996
Data Source:  BioPlex,STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
p_int:  0.999235926
p_ni:  0.000013858
p_wrong:  0.000750217
Score:  0.526
Data Source:  BioPlex,STRINGDB
PARD3
Tbio
Novelty:  0.00521327
Score:  0.994
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.992
Data Source:  STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
Score:  0.992
Data Source:  Reactome,STRINGDB
PARD6B
Tbio
Novelty:  0.08495161
Score:  0.911
Data Source:  STRINGDB
F11R
Tbio
Novelty:  0.00182817
Score:  0.908
Data Source:  Reactome,STRINGDB
PARD6A
Tbio
Novelty:  0.05667035
Score:  0.904
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
35.9
educational attainment
1
1
1
33.8
diglyceride measurement
1
1
0
1.5
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
35.9
educational attainment
1
33.8
diglyceride measurement
0
1.5
0.2
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
par-6 family cell polarity regulator gamma
VGNC:13274
738518
Macaque
par-6 family cell polarity regulator gamma
699479
Mouse
MGI:2135606
93737
Rat
RGD:1305016
307237
Dog
par-6 family cell polarity regulator gamma
VGNC:53749
483923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
par-6 family cell polarity regulator gamma
Macaque
par-6 family cell polarity regulator gamma
Mouse
Rat
Dog
par-6 family cell polarity regulator gamma
Publication Statistics
PubMed Score 4.77
PubMed score by year
PubTator Score 3.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title