Tbio NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein

Protein Summary

Description

This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9BYG3
• A8K788
• Q8TB66
• Q96ED4

Gene Name

• NIFK

Ensembl ID

• ENST00000285814
• ENSP00000285814
• ENSG00000155438

Symbol

• MKI67IP
• NOPP34
• Nopp34
• MKI67IP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
histone modification site profile	0.83
ligand (protein) perturbation	0.83
small molecule perturbation	0.82
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.76   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 381   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.76   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0