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Tbio
NIFK
MKI67 FHA domain-interacting nucleolar phosphoprotein

Protein Summary
Description
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285814
  • ENSP00000285814
  • ENSG00000155438

Symbol
  • MKI67IP
  • NOPP34
  • Nopp34
  • MKI67IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.83
ligand (protein) perturbation
0.83
small molecule perturbation
0.82
transcription factor binding site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.14   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.14   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (395)
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
p_int:  0.999877047
p_ni:  0.000122926
p_wrong:  2.7e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
CENPI
Tbio
Novelty:  0.01938121
p_int:  0.999399137
p_ni:  0.000493671
p_wrong:  0.000107193
Score:  0.528
Data Source:  BioPlex,STRINGDB
ARGLU1
Tdark
Novelty:  0.28840832
p_int:  0.99114173
p_ni:  0.000238197
p_wrong:  0.008620073
Score:  0.281
Data Source:  BioPlex,STRINGDB
CENPC
Tbio
Novelty:  0.00638662
p_int:  0.9868539
p_ni:  0.012785562
p_wrong:  0.000360537
Score:  0.211
Data Source:  BioPlex,STRINGDB
RBM19
Tbio
Novelty:  0.15784228
p_int:  0.981449932
p_ni:  0.018550068
Score:  0.908
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.976676981
p_ni:  0.023323019
Score:  0.781
Data Source:  BioPlex,STRINGDB
ZNF7
Tbio
Family:  TF
Novelty:  0.13034184
p_int:  0.973250839
p_ni:  0.025641789
p_wrong:  0.001107372
Score:  0.224
Data Source:  BioPlex,STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
p_int:  0.971542379
p_ni:  0.028103163
p_wrong:  0.000354458
Data Source:  BioPlex
UPF1
Tbio
Novelty:  0.00311006
p_int:  0.970314092
p_ni:  0.029685908
Data Source:  BioPlex
GNL2
Tbio
Novelty:  0.01792003
p_int:  0.97014562
p_ni:  0.02985438
Score:  0.989
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
1
1
0
4
35
Cough
1
1
0
4
35
high density lipoprotein cholesterol measurement
1
1
1
26.6
physical activity
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
0
4
35
Cough
0
4
35
high density lipoprotein cholesterol measurement
1
26.6
physical activity
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein interacting with the FHA domain of MKI67
VGNC:2712
459585
Macaque
nucleolar protein interacting with the FHA domain of MKI67
697198
Mouse
MGI:1915199
67949
Rat
RGD:708462
246042
Dog
nucleolar protein interacting with the FHA domain of MKI67
VGNC:43809
100856252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein interacting with the FHA domain of MKI67
Macaque
nucleolar protein interacting with the FHA domain of MKI67
Mouse
Rat
Dog
nucleolar protein interacting with the FHA domain of MKI67
Publication Statistics
PubMed Score 86.14
PubMed score by year
PubTator Score 30.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title