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Tbio
B3GNT5
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

Protein Summary
Description
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326505
  • ENSP00000316173
  • ENSG00000176597
  • ENST00000460419
  • ENSP00000420778
  • ENST00000465010
  • ENSP00000417868

Symbol
  • B3GN-T5
  • beta3Gn-T5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.79
virus perturbation
0.76
PubMedID
0.73
metabolite
0.62
cellular component
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
VGNC:11329
735383
Macaque
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
705694
Mouse
MGI:2137302
108105
Rat
RGD:70955
116740
Dog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
VGNC:38343
102154559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Macaque
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Mouse
Rat
Dog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYG0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (57)
1 – 10 of 57
MUC20
Tbio
Novelty: 0.04645313
Score: 0.96
Data Source: STRINGDB
B4GALT4
Tbio
Family: Enzyme
Novelty: 0.11226614
Score: 0.952
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01282861
Score: 0.95
Data Source: STRINGDB
MUC4
Tbio
Novelty: 0.00193208
Score: 0.947
Data Source: STRINGDB
B4GALT1
Tbio
Family: Enzyme
Novelty: 0.0073693
Score: 0.941
Data Source: STRINGDB
B4GALT2
Tbio
Family: Enzyme
Novelty: 0.03492512
Score: 0.933
Data Source: STRINGDB
B4GALT3
Tbio
Family: Enzyme
Novelty: 0.04015046
Score: 0.926
Data Source: STRINGDB
B3GALT5
Tbio
Family: Enzyme
Novelty: 0.04158039
Score: 0.91
Data Source: STRINGDB
MUC16
Tbio
Novelty: 0.00444587
Score: 0.908
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.84

PubMed score by year
PubTator Score  7.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer