Tchem ACE2 Angiotensin-converting enzyme 2

Protein Summary

Description

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity (By similarity). (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV. (Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BYF1
• C7ECU1
• Q6UWP0
• Q86WT0
• Q9NRA7
• Q9UFZ6

Gene Name

• ACE2

Ensembl ID

• ENST00000252519
• ENSP00000252519
• ENSG00000130234
• ENST00000427411
• ENSP00000389326

Symbol

• ACEH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological term	0.97
molecular function	0.86
biological process	0.78
disease	0.68

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Angiotensin-converting Enzyme 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Angiotensin-converting Enzyme 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16515.46   (req: < 5)

Gene RIFs: 914   (req: <= 3)

Antibodies: 867   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16515.46   (req: >= 5)

Gene RIFs: 914   (req: > 3)

Antibodies: 867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0