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Tbio
CDHR2
Cadherin-related family member 2

Protein Summary
Description
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261944
  • ENSP00000261944
  • ENSG00000074276
  • ENST00000506348
  • ENSP00000421078
  • ENST00000510636
  • ENSP00000424565

Symbol
  • PCDH24
  • PCLKC
  • PCLKC
  • PCDH24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
cell type or tissue
0.67
small molecule perturbation
0.62
tissue sample
0.62
cell line
0.58


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin related family member 2
VGNC:3942
462292
Macaque
cadherin related family member 2
697249
Mouse
MGI:2687323
268663
Rat
RGD:1560576
291002
Dog
cadherin related family member 2
VGNC:39038
100856325
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin related family member 2
Macaque
cadherin related family member 2
Mouse
Rat
Dog
cadherin related family member 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYE9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (33)
1 – 10 of 33
TMTC2
Tbio
Novelty: 0.17232458
p_int: 0.999636833
p_ni: 0.000019145
p_wrong: 0.000344023
Data Source: BioPlex
LAMB1
Tbio
Novelty: 0.0104285
p_int: 0.996186676
p_ni: 0.003813324
Data Source: BioPlex
NF1
Tbio
Novelty: 0.00019092
p_int: 0.989569856
p_ni: 0.010430144
Data Source: BioPlex
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.985337731
p_ni: 0.014662269
p_wrong: 1e-9
Data Source: BioPlex
LGALS1
Tchem
Novelty: 0.00106509
p_int: 0.964412231
p_ni: 0.035079409
p_wrong: 0.00050836
Data Source: BioPlex
SURF1
Tbio
Novelty: 0.00717605
p_int: 0.944392396
p_ni: 0.010524294
p_wrong: 0.04508331
Data Source: BioPlex
MRS2
Tbio
Novelty: 0.00264753
p_int: 0.891777676
p_ni: 0.108222321
p_wrong: 3e-9
Data Source: BioPlex
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.84420941
p_ni: 0.155784842
p_wrong: 0.000005748
Data Source: BioPlex
ZDHHC13
Tbio
Family: Enzyme
Novelty: 0.17442533
p_int: 0.801360046
p_ni: 0.198639953
p_wrong: 1e-9
Data Source: BioPlex
CDHR5
Tbio
Novelty: 0.08525208
Score: 0.866
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.92

PubMed score by year
PubTator Score  5.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer