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Tdark
MRPL1
39S ribosomal protein L1, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315567
  • ENSP00000315017
  • ENSG00000169288

Symbol
  • L1MT
  • BM022
  • MRP-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
histone modification site profile
0.89
kinase perturbation
0.88
protein domain
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (366)
1 – 10 of 366
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999531429
p_ni:  0.000468571
Score:  0.923
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.999087342
p_ni:  0.000912658
Score:  0.986
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.998844728
p_ni:  0.001155272
Score:  0.984
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.998571155
p_ni:  0.001428845
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.997272983
p_ni:  0.002727017
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.996411936
p_ni:  0.003588064
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL10
Tbio
Novelty:  0.27087019
p_int:  0.995995597
p_ni:  0.004004403
Score:  0.989
Data Source:  BioPlex,STRINGDB
MRPL41
Tbio
Novelty:  0.04024303
p_int:  0.992920167
p_ni:  0.007079833
Score:  0.972
Data Source:  BioPlex,STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.98749008
p_ni:  0.01250992
Score:  0.966
Data Source:  BioPlex,STRINGDB
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.981072518
p_ni:  0.018927482
Score:  0.426
Data Source:  BioPlex,STRINGDB
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L1
VGNC:748
461228
Mouse
MGI:2137202
94061
Rat
RGD:1306850
289491
Dog
mitochondrial ribosomal protein L1
VGNC:43375
478443
Horse
mitochondrial ribosomal protein L1
VGNC:20321
100059167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L1
Mouse
Rat
Dog
mitochondrial ribosomal protein L1
Horse
mitochondrial ribosomal protein L1
Publication Statistics
PubMed Score 2.94
PubMed score by year
PubTator Score 3.35
PubTator score by year