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Tdark
CNFN
Cornifelin

Protein Summary
Description
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222032
  • ENSP00000222032
  • ENSG00000105427
  • ENST00000597255
  • ENSP00000469590

Symbol
  • PLAC8L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
kinase perturbation
0.54
cell line
0.45
tissue sample
0.44
cellular component
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
84.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cornifelin
VGNC:2384
107966236
Mouse
MGI:1919633
72383
Rat
RGD:1563577
365217
Dog
cornifelin
VGNC:39394
612443
Horse
cornifelin
VGNC:16662
100069615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cornifelin
Mouse
Rat
Dog
cornifelin
Horse
cornifelin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (44)
1 – 10 of 44
LOR
Tbio
Novelty:  0.0033781
Score:  0.742
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.742
Data Source:  STRINGDB
SERPINB3
Tbio
Novelty:  0.00325244
Score:  0.721
Data Source:  STRINGDB
TMEM145
Tdark
Novelty:  2.30428448
Score:  0.703
Data Source:  STRINGDB
ETHE1
Tbio
Family:  Enzyme
Novelty:  0.01397214
Score:  0.684
Data Source:  STRINGDB
SERPINB13
Tbio
Novelty:  0.01753451
Score:  0.642
Data Source:  STRINGDB
CRNN
Tbio
Novelty:  0.01648731
Score:  0.628
Data Source:  STRINGDB
ZDHHC13
Tbio
Family:  Enzyme
Novelty:  0.17442533
Score:  0.628
Data Source:  STRINGDB
LCE3D
Tbio
Novelty:  0.20614547
Score:  0.609
Data Source:  STRINGDB
IER2
Tbio
Novelty:  0.03864806
Score:  0.603
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.28

PubMed score by year
PubTator Score  2.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer