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Tdark
MRPL4
39S ribosomal protein L4, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253099
  • ENSP00000253099
  • ENSG00000105364
  • ENST00000307422
  • ENSP00000306902
  • ENST00000590669
  • ENSP00000465143

Symbol
  • L4mt
  • CGI-28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.91
histone modification site profile
0.9
transcription factor binding site profile
0.83
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
24.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
24.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L4
VGNC:2312
455697
Macaque
mitochondrial ribosomal protein L4
715100
Mouse
MGI:2137210
66163
Rat
RGD:1311777
363023
Dog
mitochondrial ribosomal protein L4
VGNC:43397
611273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L4
Macaque
mitochondrial ribosomal protein L4
Mouse
Rat
Dog
mitochondrial ribosomal protein L4
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYD3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (417)
1 – 10 of 417
ZSWIM8
Tdark
Novelty: 0.26740136
p_int: 0.999999302
p_ni: 6.98e-7
Data Source: BioPlex
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.999998326
p_ni: 0.000001674
Score: 0.981
Data Source: BioPlex,STRINGDB
RMND5B
Tbio
Novelty: 0.08447048
p_int: 0.999992669
p_ni: 0.000007309
p_wrong: 2.3e-8
Score: 0.162
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999972766
p_ni: 0.000027234
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999968309
p_ni: 0.000031691
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL51
Tdark
Novelty: 0.24304433
p_int: 0.999929023
p_ni: 0.000070977
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.99990775
p_ni: 0.00009225
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.999882736
p_ni: 0.000117264
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL28
Tdark
Novelty: 0.23845162
p_int: 0.999858208
p_ni: 0.000141792
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL45
Tdark
Novelty: 0.42464896
p_int: 0.999794334
p_ni: 0.000205666
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.75

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer