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Tbio
MRPL13
39S ribosomal protein L13, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306185
  • ENSP00000306548
  • ENSG00000172172

Symbol
  • L13
  • L13A
  • L13mt
  • RPL13
  • RPML13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.9
histone modification site profile
0.87
virus perturbation
0.85
interacting protein
0.82


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.96   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.96   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L13
VGNC:846
464359
Macaque
mitochondrial ribosomal protein L13
702994
Mouse
MGI:2137218
68537
Rat
RGD:1359587
299938
Dog
mitochondrial ribosomal protein L13
VGNC:43378
482029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L13
Macaque
mitochondrial ribosomal protein L13
Mouse
Rat
Dog
mitochondrial ribosomal protein L13
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (398)
1 – 10 of 398
MRPL51
Tdark
Novelty:  0.24304433
p_int:  0.999952329
p_ni:  0.000047665
p_wrong:  6e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
MRPL55
Tdark
Novelty:  0.55956177
p_int:  0.999844967
p_ni:  0.000155033
Score:  0.992
Data Source:  BioPlex,STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.999843583
p_ni:  0.000156417
Score:  0.219
Data Source:  BioPlex,STRINGDB
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.99967876
p_ni:  0.00032124
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL33
Tdark
Novelty:  0.49802524
p_int:  0.99960694
p_ni:  0.000390956
p_wrong:  0.000002103
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL34
Tdark
Novelty:  1.17388411
p_int:  0.999490522
p_ni:  0.000509478
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.99947736
p_ni:  0.00052264
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999428065
p_ni:  0.000571935
Score:  0.995
Data Source:  BioPlex,STRINGDB
MRPL57
Tdark
Novelty:  1.55023434
p_int:  0.999366975
p_ni:  0.000633025
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL17
Tdark
Novelty:  1.20541719
p_int:  0.999186559
p_ni:  0.000813441
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.96

PubMed score by year
PubTator Score  21.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer