You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
MRPL20
39S ribosomal protein L20, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344843
  • ENSP00000341082
  • ENSG00000242485
  • ENST00000482352
  • ENSP00000460924

Symbol
  • L20mt
  • MRP-L20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
virus perturbation
0.85
kinase perturbation
0.81
disease perturbation
0.74
cellular component
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2137221
66448
Rat
RGD:1588219
680747
Dog
mitochondrial ribosomal protein L20
VGNC:43385
479569
Cow
mitochondrial ribosomal protein L20
VGNC:31624
506358
Opossum
mitochondrial ribosomal protein L20
100011440
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitochondrial ribosomal protein L20
Cow
mitochondrial ribosomal protein L20
Opossum
mitochondrial ribosomal protein L20
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYC9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (240)
1 – 10 of 240
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.99964171
p_ni: 0.00035829
Score: 0.986
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999615363
p_ni: 0.000384637
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.999570456
p_ni: 0.000429544
Score: 0.999
Data Source: BioPlex,STRINGDB
RHOT2
Tbio
Family: Enzyme
Novelty: 0.01712732
p_int: 0.998412699
p_ni: 0.001587301
Score: 0.181
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.997882604
p_ni: 0.002117396
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.996940616
p_ni: 0.003059384
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.996280498
p_ni: 0.003719502
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.996038177
p_ni: 0.003961823
Score: 0.985
Data Source: BioPlex,STRINGDB
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.994593604
p_ni: 0.005406396
Data Source: BioPlex
RPL37
Tbio
Novelty: 0.03935854
p_int: 0.993869849
p_ni: 0.006130151
Data Source: BioPlex
Publication Statistics
PubMed Score  0.89

PubMed score by year
PubTator Score  0.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer