MRPL32
39S ribosomal protein L32, mitochondrial
Protein Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]
- ENST00000223324
- ENSP00000223324
- ENSG00000106591
- L32mt
- HSPC283
- MRP-L32
- bMRP-59b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.85 | ||
kinase perturbation | 0.76 | ||
cell type or tissue | 0.73 | ||
tissue sample | 0.67 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.26 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 79 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.26 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 79 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (230)
MRPL47
Novelty: 0.05648009
p_int: 0.999618573
p_ni: 0.000380968
p_wrong: 4.58e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS30
Novelty: 0.08115544
p_int: 0.9991009
p_ni: 0.000899058
p_wrong: 4.1e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
MRPL10
Novelty: 0.27087019
p_int: 0.998851913
p_ni: 0.001148085
p_wrong: 2e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
MRPL13
Novelty: 0.04173503
p_int: 0.998528525
p_ni: 0.001469746
p_wrong: 0.000001729
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL30
Novelty: 1.03623556
p_int: 0.998464846
p_ni: 0.001535152
p_wrong: 2e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
MRPL41
Novelty: 0.04024303
p_int: 0.997561101
p_ni: 0.002438896
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL4
Novelty: 0.27290276
p_int: 0.997554827
p_ni: 0.002444255
p_wrong: 9.18e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL18
Novelty: 0.73438796
p_int: 0.996889786
p_ni: 0.003110208
p_wrong: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL53
Novelty: 1.0076471
p_int: 0.996608206
p_ni: 0.003306499
p_wrong: 0.000085296
Score: 0.985
Data Source: BioPlex,STRINGDB
MRPL50
Novelty: 0.88879319
p_int: 0.988335341
p_ni: 0.011658422
p_wrong: 0.000006237
Score: 0.997
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial translation | ||||
Reactome | Mitochondrial translation elongation | ||||
Reactome | Mitochondrial translation initiation | ||||
Reactome | Mitochondrial translation termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Mitochondrial translation | ||||
Mitochondrial translation elongation | ||||
Mitochondrial translation initiation | ||||
Mitochondrial translation termination | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L32 | VGNC:4433 | 472652 | |||||
Mouse | MGI:2137226 | 75398 | ||||||
Rat | RGD:1310541 | 291206 | ||||||
Dog | mitochondrial ribosomal protein L32 | VGNC:43391 | 475869 | |||||
Horse | mitochondrial ribosomal protein L32 | 100051571 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L32 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrial ribosomal protein L32 | |||||
Horse | mitochondrial ribosomal protein L32 | |||||
Publication Statistics
PubMed Score 1.26
PubMed score by year
PubTator Score 1.82
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (1)
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