MRPL32
39S ribosomal protein L32, mitochondrial
Protein Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]
- ENST00000223324
- ENSP00000223324
- ENSG00000106591
- L32mt
- HSPC283
- MRP-L32
- bMRP-59b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.85 | ||
kinase perturbation | 0.76 | ||
cell type or tissue | 0.73 | ||
tissue sample | 0.67 | ||
virus perturbation | 0.64 | ||
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.26 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 79 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.26 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 79 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L32 | VGNC:4433 | 472652 | |||||
Mouse | MGI:2137226 | 75398 | ||||||
Rat | RGD:1310541 | 291206 | ||||||
Dog | mitochondrial ribosomal protein L32 | VGNC:43391 | 475869 | |||||
Horse | mitochondrial ribosomal protein L32 | 100051571 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L32 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrial ribosomal protein L32 | |||||
Horse | mitochondrial ribosomal protein L32 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial translation | ||||
Reactome | Mitochondrial translation elongation | ||||
Reactome | Mitochondrial translation initiation | ||||
Reactome | Mitochondrial translation termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Mitochondrial translation | ||||
Mitochondrial translation elongation | ||||
Mitochondrial translation initiation | ||||
Mitochondrial translation termination | ||||
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (230)
1 – 10 of 230
MRPL47
Novelty: 0.05648009
p_int: 0.999618573
p_ni: 0.000380968
p_wrong: 4.58e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS30
Novelty: 0.08115544
p_int: 0.9991009
p_ni: 0.000899058
p_wrong: 4.1e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
MRPL10
Novelty: 0.27087019
p_int: 0.998851913
p_ni: 0.001148085
p_wrong: 2e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
MRPL13
Novelty: 0.04173503
p_int: 0.998528525
p_ni: 0.001469746
p_wrong: 0.000001729
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL30
Novelty: 1.03623556
p_int: 0.998464846
p_ni: 0.001535152
p_wrong: 2e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
MRPL41
Novelty: 0.04024303
p_int: 0.997561101
p_ni: 0.002438896
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL4
Novelty: 0.27290276
p_int: 0.997554827
p_ni: 0.002444255
p_wrong: 9.18e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL18
Novelty: 0.73438796
p_int: 0.996889786
p_ni: 0.003110208
p_wrong: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL53
Novelty: 1.0076471
p_int: 0.996608206
p_ni: 0.003306499
p_wrong: 0.000085296
Score: 0.985
Data Source: BioPlex,STRINGDB
MRPL50
Novelty: 0.88879319
p_int: 0.988335341
p_ni: 0.011658422
p_wrong: 0.000006237
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 1.26
PubMed score by year
PubTator Score 1.82
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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