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Tbio
FUT8
Alpha-(1,6)-fucosyltransferase

Protein Summary
Description
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342677
  • ENSP00000345865
  • ENSG00000033170
  • ENST00000360689
  • ENSP00000353910
  • ENST00000394586
  • ENSP00000378087
  • ENST00000557164
  • ENSP00000452433

Symbol
  • CDGF
  • CDGF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.91
kinase perturbation
0.88
transcription factor
0.86
PubMedID
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.57   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.57   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
N-glycan measurement
2
3
8
88
hematocrit
2
2
2
78.4
high density lipoprotein cholesterol measurement
1
1
1
62.7
hemoglobin measurement
1
1
1
24.6
age at menarche
1
1
1
23.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
N-glycan measurement
8
88
hematocrit
2
78.4
high density lipoprotein cholesterol measurement
1
62.7
hemoglobin measurement
1
24.6
age at menarche
1
23.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 8
VGNC:10245
449506
Macaque
fucosyltransferase 8
708839
Mouse
MGI:1858901
53618
Rat
RGD:1303096
432392
Dog
fucosyltransferase 8
VGNC:41015
448804
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 8
Macaque
fucosyltransferase 8
Mouse
Rat
Dog
fucosyltransferase 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYC5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Reactome
Post-translational protein modification
Reactome
Reactions specific to the complex N-glycan synthesis pathway
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan antennae elongation in the medial/trans-Golgi
Post-translational protein modification
Reactions specific to the complex N-glycan synthesis pathway
Protein-Protein Interactions (117)
1 – 10 of 117
SLC9A6
Tbio
Family: Transporter
Novelty: 0.01410234
p_int: 0.999966616
p_ni: 0.000033384
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999825517
p_ni: 0.000174483
Data Source: BioPlex
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.999680204
p_ni: 0.000319784
p_wrong: 1.2e-8
Data Source: BioPlex
MAN2A2
Tbio
Family: Enzyme
Novelty: 0.07098345
p_int: 0.999669165
p_ni: 0.000330835
Score: 0.634
Data Source: BioPlex,STRINGDB
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
p_int: 0.998261116
p_ni: 0.001738884
Data Source: BioPlex
GABRD
Tclin
Family: IC
Novelty: 0.0204242
p_int: 0.99816816
p_ni: 0.00183184
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.998119565
p_ni: 0.001880435
Data Source: BioPlex
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
p_int: 0.997259439
p_ni: 0.002740561
Data Source: BioPlex
STS
Tchem
Family: Enzyme
Novelty: 0.00324549
p_int: 0.996595556
p_ni: 0.003403752
p_wrong: 6.92e-7
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.991962351
p_ni: 0.008037642
p_wrong: 7e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  178.57

PubMed score by year
PubTator Score  97.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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