FUT8
Alpha-(1,6)-fucosyltransferase
Protein Summary
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
- ENST00000342677
- ENSP00000345865
- ENSG00000033170
- ENST00000360689
- ENSP00000353910
- ENST00000394586
- ENSP00000378087
- ENST00000557164
- ENSP00000452433
- CDGF
- CDGF1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.98 | ||
transcription factor binding site profile | 0.91 | ||
kinase perturbation | 0.88 | ||
transcription factor | 0.86 | ||
PubMedID | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 212.96 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 216 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 212.96 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 216 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0