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Tbio
OXCT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

Protein Summary
Description
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327582
  • ENSP00000361914
  • ENSG00000198754

Symbol
  • SCOTT
  • FKSG25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell line
0.67
tissue sample
0.65
pathway
0.59
small molecule perturbation
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
OXCT1
Tbio
Family:  Enzyme
Novelty:  0.00283394
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.87
Data Source:  BioPlex,STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.989245664
p_ni:  0.010754245
p_wrong:  9.2e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
p_int:  0.811357328
p_ni:  0.188642672
Score:  0.486
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.803147315
p_ni:  0.196852685
Score:  0.164
Data Source:  BioPlex,STRINGDB
ATPAF1
Tbio
Family:  Enzyme
Novelty:  0.04032579
p_int:  0.768361777
p_ni:  0.231638223
Score:  0.216
Data Source:  BioPlex,STRINGDB
ACAT1
Tchem
Family:  Enzyme
Novelty:  0.00908928
Score:  0.964
Data Source:  STRINGDB
BDH1
Tbio
Family:  Enzyme
Novelty:  0.01229995
Score:  0.956
Data Source:  STRINGDB
BDH2
Tbio
Family:  Enzyme
Novelty:  0.04118875
Score:  0.956
Data Source:  STRINGDB
ACAT2
Tchem
Family:  Enzyme
Novelty:  0.01464168
Score:  0.95
Data Source:  STRINGDB
HMGCL
Tbio
Family:  Enzyme
Novelty:  0.02741994
Score:  0.948
Data Source:  STRINGDB
Pathways (9)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Utilization of Ketone Bodies
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
Utilization of Ketone Bodies
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
73.7
peptidyl-prolyl cis-trans isomerase E measurement
1
1
1
66.4
myeloid white cell count
1
1
1
33.8
1
1
1
27.9
substance abuse
1
1
1
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
73.7
peptidyl-prolyl cis-trans isomerase E measurement
1
66.4
myeloid white cell count
1
33.8
1
27.9
substance abuse
1
27.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891061
64059
Mouse
MGI:2664115
353371
Fruitfly
FBgn0035298
38261
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Mouse
Fruitfly
Publication Statistics
PubMed Score 16.08
PubMed score by year
PubTator Score 3.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title